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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제1호
- 발행연도
- 2018.1
- 수록면
- 109 - 114 (6page)
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초록· 키워드
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Coxsackievirus Type B3 (CVB3) is an enterovirus that belongs to the Picornaviridae and causes various diseases such as myocarditis and hand-foot-mouth disease. However, an effective antiviral drug is still not developed. In this study, we looked for potential inhibitors of CVB3 replication by examining the survival of CVB3-infected HeLa cells. We detected an antiviral effect by cholic acid and identified it as a candidate inhibitor of CVB3 replication. Cholic acid circulates in the liver and intestines, and it helps the digestion and absorption of lipids in the small intestine. HeLa cells were cultured in 12-well plates and treated with cholic acid (1 and 10 μg/ml) and 106 PFU/ml of CVB3. After 16 h post-infection, the cells were lysed and subjected to western blot analysis and RT-PCR. The production of the viral capsid protein VP1 was dramatically decreased, and translation initiation factor eIF4G1 cleavage was significantly inhibited by treatment with 10 μg/ml cholic acid. Moreover, cholic acid inhibited ERK signaling in CVB3–infected HeLa cells. RT-PCR showed that the amounts of the CVB3 RNA genome and mRNA for the ER stress-related transcription factor ATF4 were significantly reduced. These results showed that cholic acid strongly reduced ER stress and CVB3 proliferation. This compound can be developed as a safe natural therapeutic agent for enterovirus infections.
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참고문헌 (24)
참고문헌 신청
Feldman AM / 2000 / Myocarditis / N. Engl. J. Med. 343:1388~1398
Lim BK / 2008 / Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart / J. Clin. Invest. 118:2758~2770
Knowlton KU / 1996 / A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3 / J. Virol. 70:7811~7818
Knowlton KU / 1999 / The immune system in viral myocarditis: maintaining the balance / Circ. Res. 85:559~561
Xiong D / 2007 / Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy / Circulation 115:94~102
Lim BK / 2008 / Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart / J. Clin. Invest. 118:2758~2770
Knowlton KU / 1996 / A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3 / J. Virol. 70:7811~7818
Knowlton KU / 1999 / The immune system in viral myocarditis: maintaining the balance / Circ. Res. 85:559~561
Xiong D / 2007 / Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy / Circulation 115:94~102
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