지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.2
- 수록면
- 3 - 8 (6page)
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Functional damage to microvascular endothelial cells by hyperglycemia is thought to be one of the critical risk factors in the impaired wound healing seen with diabetes mellitus. It is also thought that oxidative stress plays a significant role in this endothelial cell dysfunction. The present study examined the differential effects of flavonoids on endothelial cell dysfunction under high glucose condition. Human endothelial cells exposed to 30 m㏖/ℓ glucose for 7 d were pre-treated with various flavonoids and pulse-treated with 0.2 m㏖/ℓ H₂O₂ for 30 min. High glucose markedly decreased cell viability with elevated oxidant generation and nuclear condensation, H₂O₂ insult exacerbated endothelial cytotoxicity due to chronic exposure to high glucose. (-)Epigallocatechin gallate and quercetin improved glucose-induced cell damage with the disappearance of apoptotic bodies, whereas apigenin intensified the glucose cytotoxicity. In addition, cell viability data revealed that these flavonoids of (-)epigallocatechin gallate and quercetin substantially attenuated both high glucose- and H₂O₂- induced dual endothelial damage. 'These results suggest that (- )epigallocatechin gallate and quercetin may be beneficial agents for improving endothelial cell dysfunction induced by high glucose and may prevent or reduce the development of diabetic vascular complications.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
Literature cited
참고문헌 (25)
참고문헌 신청
, 1992 , Glucose and diabetic vascular disease 6 : 2905 ~ 2914
, 2006 , Glucose induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy 55 : 225 ~ 233
, 2005 , Endothelial cell injury by high glucose and heparanase is prevented by insulin heparin and basic fibroblast growth factor 4 : 1 ~ 12
, 2006 , Activation of AMP Activated protein kinase reduces yperglycemiainducedmitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells 55 : 120 ~ 127
, 2005 , High glucose induces human endothelial cell apoptosis through a phosphoinositide 3 kinase regulated cyclooxygenase 2 pathway 25 : 539 ~ 545
, 2006 , Glucose induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy 55 : 225 ~ 233
, 2005 , Endothelial cell injury by high glucose and heparanase is prevented by insulin heparin and basic fibroblast growth factor 4 : 1 ~ 12
, 2006 , Activation of AMP Activated protein kinase reduces yperglycemiainducedmitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells 55 : 120 ~ 127
, 2005 , High glucose induces human endothelial cell apoptosis through a phosphoinositide 3 kinase regulated cyclooxygenase 2 pathway 25 : 539 ~ 545
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UCI(KEPA) : I410-ECN-0101-2012-594-004194669