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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제9호
- 발행연도
- 2008.1
- 수록면
- 1,590 - 1,598 (9page)
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초록· 키워드
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Cell proliferation and differentiation are critical processes in a developing fetal rat brain, during which programmed cell death (PCD) also plays an important role. One of the decisive factors for PCD is Bcl-2 family proteins, where Bax induces cell death, whereas Bcl-2 acts as an inhibitor of PCD. As maternal drinking is known to cause fetal alcohol syndrome (FAS) or malformation of the fetal brain during pregnancy, the objective of the present study was to investigate whether maternal ethanol exposure alters the PCD-related Bax and Bcl-2 protein expression during fetal brain development. Pregnant female rats were orally treated with 10% ethanol and the subsequent expressions of the Bax and Bcl-2 proteins examined in the fetal brain, including the forebrain, midbrain, and hindbrain, from gestational day (GD) 15.5 to GD 19.5, using Western blots, in situ hybridization, and immunohistochemistry. With regard to the ratio of Bcl-2 to Bax proteins (Bcl-2/Bax), the Bax protein was dominant in the forebrain and midbrain of the control GD 15.5 fetuses, except for the hindbrain, when compared with the respective ethanol-treated groups.
Moreover, Bcl-2 became dominant in the midbrain of the control GD 17.5 fetuses when compared with the ethanoltreated group, representing an alternation of the natural PCD process by ethanol. Furthermore, a differential expression of the Bcl-2 and Bax proteins was found in the differentiating and migrating zones of the cortex, hippocampus, thalamus, and cerebellum. Thus, when taken together, the present results suggest that ethanol affects PCD in the cell differentiation and migration zones of the prenatal rat brain by modulating Bax and Bcl-2 expression in an age- and area-dependent manner. Therefore, this is the first evidence that ethanol may alter FAS-associated embryonic brain development through the alteration of Bax and Bcl-2 expression.
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참고문헌 (24)
참고문헌 신청
[
Adrain, C. / 2001 / The mitochondrial apoptosome: A killer unleashed by the cytochrome c / Trends Biochem. Sci 26 : 390 ~ 397
Altman, J. / 1995 / Atlas of Prenatal Rat Brain Development / CRC Press : 206 ~ 467
Bae, Jinhee / 2008 / Interleukin-2 Promotes Angiogenesis by Activation of Akt and Increase of ROS / Journal of Microbiology and Biotechnology 18 (2) : 377 ~ 382
Bibel, M. / 2000 / Neurotrophins: Key regulators of cell fate and cell shape in the vertebrate nervous system / Genes Dev 14 : 2919 ~ 2937
Adrain, C. / 2001 / The mitochondrial apoptosome: A killer unleashed by the cytochrome c / Trends Biochem. Sci 26 : 390 ~ 397
Altman, J. / 1995 / Atlas of Prenatal Rat Brain Development / CRC Press : 206 ~ 467
Bae, Jinhee / 2008 / Interleukin-2 Promotes Angiogenesis by Activation of Akt and Increase of ROS / Journal of Microbiology and Biotechnology 18 (2) : 377 ~ 382
Bibel, M. / 2000 / Neurotrophins: Key regulators of cell fate and cell shape in the vertebrate nervous system / Genes Dev 14 : 2919 ~ 2937
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