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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제9호
- 발행연도
- 2008.1
- 수록면
- 1,485 - 1,491 (7page)
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Tylosin biosynthesis is controlled in cascade fashion by
multiple transcriptional regulators, acting positively or
negatively, in conjunction with a signalling ligand that
acts as a classical inducer. The roles of regulatory gene
products have been characterized by a combination of
gene expression analysis and fermentation studies, using
engineered strains of S. fradiae in which specific genes
were inactivated or overexpressed. Among various novel
features of the regulatory model, involvement of the
signalling ligand is not essential for tylosin biosynthesis.
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참고문헌 (22)
참고문헌 신청
Arisawa, A / 1996 / Direct fermentative production of acyltylosins by genetically-engineered strains of Streptomyces fradiae / J. Antibiot 49 : 349 ~ 354
Bate, N / 1999 / Multiple regulatory genes in the tylosin-biosynthetic cluster of Streptomyces fradiae / Chem. Biol 6 : 617 ~ 624
Bate, N. / 2002 / Differential roles of two SARP-encoding regulatory genes during tylosin biosynthesis. Mol / Microbiol 43 : 449 ~ 458
Bate, N. / 2006 / Regulation of tylosin biosynthesis involving ‘SARP-helper’ activity. Mol / Microbiol 62 : 148 ~ 156
Bibb, M. J. / 2005 / Regulation of secondary metabolism in streptomycetes. Curr. Opin / Microbiol 8 : 208 ~ 215
Bate, N / 1999 / Multiple regulatory genes in the tylosin-biosynthetic cluster of Streptomyces fradiae / Chem. Biol 6 : 617 ~ 624
Bate, N. / 2002 / Differential roles of two SARP-encoding regulatory genes during tylosin biosynthesis. Mol / Microbiol 43 : 449 ~ 458
Bate, N. / 2006 / Regulation of tylosin biosynthesis involving ‘SARP-helper’ activity. Mol / Microbiol 62 : 148 ~ 156
Bibb, M. J. / 2005 / Regulation of secondary metabolism in streptomycetes. Curr. Opin / Microbiol 8 : 208 ~ 215
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