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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제26권 제5호
- 발행연도
- 2016.1
- 수록면
- 876 - 882 (7page)
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Tylosin has been used as a livestock feed additive and antibiotic growth promoter for many years. However, the mode of action by which tylosin enhances animal growth is unclear. We used high-throughput sequencing of 16S rRNA genes to investigate the effects of tylosin as a feed additive on swine gut microbiota. No significant difference in the rate of weight increase was observed between control and tylosin-treated pigs during a 10-week feeding trial. However, tylosin-treated pigs showed rapid increases in the relative abundance of the phylum Firmicutes. Increases in Firmicutes species are associated with (so-called) obese-type gut microbiota. The abundance of species of four families of the phylum Firmicutes (Streptococcaceae, Peptococcaceae, Peptostreptococcaceae, and Clostridiaceae) correlated positively with host weight gain. The abundance of Streptococcaceae family bacteria was least affected by tylosin treatment. Distribution analysis of operational taxonomic units (OTUs) showed that both control and tylosin-treated pigs exhibited similar OTU alterations during growth. However, the tylosin-treated group showed distinctive alterations in gut microbiota when the host weighed approximately 60 kg, whereas similar alterations occurred at around 80 kg in the control group. Our results suggest that use of tylosin accelerates maturation of swine gut microbiota rather than altering its composition.
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참고문헌 (50)
참고문헌 신청
Biddle AS / 2013 / An in vitro model of the horse gut microbiome enables identification of lactate-utilizing bacteria that differentially respond to starch induction / PLoS One 8:e77599
Blackwood RS / 2008 / Effects of the macrolide drug tylosin on chronic diarrhea in rhesus macaques (Macaca mulatta) / Comp. Med 58:81~87
Cole JR / 2009 / The Ribosomal Database Project: improved alignments and new tools for rRNA analysis / Nucleic Acids Res 37:D141~D145
Collier CT / 2003 / Effects of tylosin on bacterial mucolysis, Clostridium perfringens colonization, and intestinal barrier function in a chick model of necrotic enteritis / Antimicrob. Agents Chemother 47:3311~3317
Cox LM / 2015 / Antibiotics in early life and obesity / Nat. Rev. Endocrinol 11:182~190
Blackwood RS / 2008 / Effects of the macrolide drug tylosin on chronic diarrhea in rhesus macaques (Macaca mulatta) / Comp. Med 58:81~87
Cole JR / 2009 / The Ribosomal Database Project: improved alignments and new tools for rRNA analysis / Nucleic Acids Res 37:D141~D145
Collier CT / 2003 / Effects of tylosin on bacterial mucolysis, Clostridium perfringens colonization, and intestinal barrier function in a chick model of necrotic enteritis / Antimicrob. Agents Chemother 47:3311~3317
Cox LM / 2015 / Antibiotics in early life and obesity / Nat. Rev. Endocrinol 11:182~190
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