지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 17 - 24 (8page)
이용수
초록· 키워드
오류제보하기
Prostanoid metabolites are key mediators in inflammatory
responses, and accumulating evidence
suggests that mesenchymal stem cells (MSCs) can be
recruited to injured or inflamed tissues. In the present
study, we investigated whether prostanoid metabolites
can regulate migration, proliferation, and differentiation
potentials of MSCs. We demonstrated herein
that the stable thromboxane A2 (TxA2) mimetic U46619
strongly stimulated migration and proliferation of human
adipose tissue-derived MSCs (hADSCs). Furthermore,
U46619 treatment increased expression of
α-smooth muscle actin (α-SMA), a smooth muscle
marker, in hADSCs, suggesting differentiation of
hADSCs into smooth muscle-like cells. U46619 activated
ERK and p38 MAPK, and pretreatment of the cells
with the MEK inhibitor U0126 or the p38 MAPK inhibitor
SB202190 abrogated the U46619-induced migration,
proliferation, and α-SMA expression. These results
suggest that TxA2 plays a key role in the migration, proliferation,
and differentiation of hADSCs into smooth
muscle-like cells through signaling mechanisms involving
ERK and p38 MAPK.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Barry FP / 2004 / Murphy JM. Mesenchymal stem cells: clinical applications and biological characterization / Int J Biochem Cell Biol 36 : 568 ~ 584
Bos CL / 2004 / Prostanoids and prostanoid receptors in signal transduction / Int J Biochem Cell Biol 36 : 1187 ~ 1205
Chamberlain G / 2007 / Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing / Stem Cells 25 : 2
Davani S / 2003 / Mesenchymal progenitor cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a rat cellular cardiomyopl
Dogne JM / 2005 / Thromboxane, prostacyclin and isoprostanes: therapeutic targets in atherogenesis / Trends Pharmacol Sci : 639 ~ 644
Bos CL / 2004 / Prostanoids and prostanoid receptors in signal transduction / Int J Biochem Cell Biol 36 : 1187 ~ 1205
Chamberlain G / 2007 / Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing / Stem Cells 25 : 2
Davani S / 2003 / Mesenchymal progenitor cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a rat cellular cardiomyopl
Dogne JM / 2005 / Thromboxane, prostacyclin and isoprostanes: therapeutic targets in atherogenesis / Trends Pharmacol Sci : 639 ~ 644
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
MicroRNA-103a-3p controls proliferation and osteogenic differentiation of human adipose tissue-derived stromal cells
Experimental and Molecular Medicine
2015 .01
-
MicroRNA-200a/210 Controls Proliferation and Osteogenic Differentiation of Human Adipose Tissue Stromal Cells
생명과학회지
2017 .07
-
Mesenchymal stem cells promote proliferation of endogenous neural stem cells and survival of newborn cells in a rat stroke model
Experimental and Molecular Medicine
2008 .01
-
Soluble mediators from mesenchymal stem cells suppress T cell proliferation by inducing IL-10
Experimental and Molecular Medicine
2009 .01
-
Sphingosine-1-Phosphate-Induced Migration and Differentiation of Human Mesenchymal Stem Cells to Smooth Muscle Cells
생명과학회지
2011 .02
-
Role of Non-Thermal DBD Plasma on Cell Migration and Cell Proliferation in Wound Healing
한국진공학회 학술발표회초록집
2013 .02
-
The p38 mitogen-activated protein kinase is involved in stress-induced phospholipase D activation in vascular smooth muscle cells
Experimental and Molecular Medicine
2002 .01
-
Differentiation of mesenchymal stem cells on nanopillar/pit array structures
한국진공학회 학술발표회초록집
2017 .02
-
인체 지방 유래 중간엽 줄기세포의 골분화 조절 기전에서 NFAT5의 역할
생명과학회지
2013 .04
-
Dynamic changes of gangliosides expression during thedifferentiation of embryonic and mesenchymal stem cellsinto neural cells
Experimental and Molecular Medicine
2006 .01
-
The effect of ferulic acid ethyl ester on leptin-induced proliferation and migration of aortic smooth muscle cells
Experimental and Molecular Medicine
2015 .01
-
Simvastatin inhibits sphingosylphosphorylcholine-induced differentiation of human mesenchymal stem cells into smooth muscle cells
Experimental and Molecular Medicine
2012 .01
-
Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine
Experimental and Molecular Medicine
2013 .01
-
Regeneration of Cardiovascular Tissues using Tissue Engineering and Mesenchymal Stem Cells
한국생명과학회 심포지움
2003 .10
-
Nuclear receptor regulation of stemness and stem cell differentiation
Experimental and Molecular Medicine
2009 .01
-
Effect of Histone Deacetylase Inhibitors on Differentiation of Human Bone Marrow-derived Stem Cells Into Neuron-like Cells
조선자연과학논문집
2019 .01
-
Aster tataricus 물 추출물의 mitogen-activated protein kinase 신호 전달 경로를 통한 면역 조절 효과
Journal of Nutrition and Health
2020 .10
-
Differentiation of human gingival mesenchymal stem cells into neuronal lineages in 3D bioconjugated injectable protein hydrogel construct for the management of neuronal disorder
Experimental and Molecular Medicine
2016 .01
-
The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells
Molecules and Cells
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0