지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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- 학술저널
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- 2013.1
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Mesenchymal stem cells (MSCs) are partially defined by their ability to differentiate into tissues including bone, cartilage and adipose in vitro, but it is their trophic, paracrine and immunomodulatory functions that may have the greatest therapeutic impact in vivo. Unlike pharmaceutical treatments that deliver a single agent at a specific dose, MSCs are site regulated and secrete bioactive factors and signals at variable concentrations in response to local microenvironmental cues. Significant progress has been made in understanding the biochemical and metabolic mechanisms and feedback associated with MSC response. The anti-inflammatory and immunomodulatory capacity of MSC may be paramount in the restoration of localized or systemic conditions for normal healing and tissue regeneration. Allogeneic MSC treatments, categorized as a drug by regulatory agencies, have been widely pursued, but new studies demonstrate the efficacy of autologous MSC therapies, even for individuals affected by a disease state. Safety and regulatory concerns surrounding allogeneic cell preparations make autologous and minimally manipulated cell therapies an attractive option for many regenerative, anti-inflammatory and autoimmune applications.
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참고문헌 (27)
참고문헌 신청
Bianco P / 1988 / Alkaline phosphatase positive precursors of adipocytes in the human bone marrow / Br J Haematol 68 : 401 ~ 403
Bianco P / 1999 / Multipotential cells in the bone marrow stroma: regulation in the context of organ physiology / Crit Rev Eukaryot Gene Expr 9 : 159 ~ 173
Caplan A / 1991 / Mesenchymal stem cells / J Orthop Res 9 : 641 ~ 650
Caplan AI / 2007 / Adult mesenchymal stem cells for tissue engineering versus regenerative medicine / J Cell Physiol 213 : 341 ~ 347
Caplan AI / 2008 / All MSCs are pericytes? / Cell Stem Cell 3 : 229 ~ 230
Bianco P / 1999 / Multipotential cells in the bone marrow stroma: regulation in the context of organ physiology / Crit Rev Eukaryot Gene Expr 9 : 159 ~ 173
Caplan A / 1991 / Mesenchymal stem cells / J Orthop Res 9 : 641 ~ 650
Caplan AI / 2007 / Adult mesenchymal stem cells for tissue engineering versus regenerative medicine / J Cell Physiol 213 : 341 ~ 347
Caplan AI / 2008 / All MSCs are pericytes? / Cell Stem Cell 3 : 229 ~ 230
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