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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 255 - 260 (6page)
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Sec13p has been known as an endoplasmic reti-culum-Golgi transport protein. Recently, it has also been shown to be required for the formation of septation in the fission yeast Schizosaccharo-myces pombe. In the present study, we focused on the role of a human homolog of Saccharo-myces cerevisiae SEC13, Sec13 protein during mitosis in U2OS cels. We found that the ex-presion of Sec13 was constant throughout the cel cycle, and localized to the kinetochores at metaphase during mitosis. By using gren fluo-rescent protein technology, we observed that Sec13 is required for evasion of mitotic arrest in response to spindle damage, leading to G1-like phase and apoptotic cell death. In addition, cels expressing exogenous Sec13 showed giant nu-clei compared to endogenous ones in the ab-sence of nocodazole. These results demonstrate that Sec13 is involved in the regulation of the metaphase/anaphase transition and may be func-tionaly associated with mitotic machinery to maintain genomic stability during mitosis.
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참고문헌 (25)
참고문헌 신청
/ / Analysis of the physical properties and molecularmodeling of Sec13 A WD repeat protein involved in vesiculartraffic : 15215 ~ 21
/ / CytosolicSec13p complex is required for vesicle formation from theendoplasmic reticulum in vitro 120 : 865 ~ 75
/ / G1 tetraploidycheckpoint and the suppression of tumorigenesis : 673 ~ 83
/ / Golgi membrane vesicles in HeLamitotic cells are identified with monoclonal antibody madeagainst Golgi cisternal membrane protein p138 : 445 ~ 53
/ / Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1 93 : 81 ~ 91
/ / CytosolicSec13p complex is required for vesicle formation from theendoplasmic reticulum in vitro 120 : 865 ~ 75
/ / G1 tetraploidycheckpoint and the suppression of tumorigenesis : 673 ~ 83
/ / Golgi membrane vesicles in HeLamitotic cells are identified with monoclonal antibody madeagainst Golgi cisternal membrane protein p138 : 445 ~ 53
/ / Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1 93 : 81 ~ 91
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