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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 482 - 487 (6page)
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Multinucleated cells resulted from mitosis defect have been noted in pathophysiological statesof the cells such as inflammation, senescence and cancer. Since oxidative stress has been known to correlate with these pathophysiological conditions, we tested the effect of H2O2 on the cell cycle progression and formation of multinucleated cells. H2O2 induced a significant delay in cell cycle progression in Chang liver cells. Interestingly, H2O2 actively induced hyper-amplification of centrosomes (n ≥ 3) and multipolar spindle formationduring mitosis and subsequently increased the generation ofmultinucleated cells. A significant increase of the phospho-ERK level was observed upon H2O2 treatment but PD98059, an MEK1/2 inhibitor, didnt reduce the frequency of cels with hyperamplified centrosomes. On the 2O2 or adriamycin increased intracellular ROS levels and multinu-cleated cels, which were significantly supres-sed by antioxidants, N-acetylcysteine and PDTC. Thus, our results suggest that oxidative stress can triger centrosome hyperamplification and multinucleated cell formation, which may pro-mote pathophysiological progresion.
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참고문헌 (24)
참고문헌 신청
/ / Centrosome andmicrotubule instability in aging Drosophila cells : 229 ~ 41
/ / Centrosome disorganization infibroblast cultures derived from R6/2 Huntington's disease : 2425 ~ 35
/ / Doxorubicin treatment in vivo causes cytochrome Crelease and cardiomyocyte apoptosis as well as increasedmitochondrial efficiency
/ / Gene-diet interactions in brain aging andneurodegenerative disorders : 441 ~ 4
/ / Induction of centrosome amplification andchromosome instability in human bladder cancer cells byp53 mutation and cyclin E overexpression (jima t) : 2065 4800 ~ 9
/ / Centrosome disorganization infibroblast cultures derived from R6/2 Huntington's disease : 2425 ~ 35
/ / Doxorubicin treatment in vivo causes cytochrome Crelease and cardiomyocyte apoptosis as well as increasedmitochondrial efficiency
/ / Gene-diet interactions in brain aging andneurodegenerative disorders : 441 ~ 4
/ / Induction of centrosome amplification andchromosome instability in human bladder cancer cells byp53 mutation and cyclin E overexpression (jima t) : 2065 4800 ~ 9
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