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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 189 - 195 (7page)
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초록· 키워드
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portant role in the physiology of vasculature, blod presure and inflamation. ACE gene, known to have insertion/deletion (I/D) polymorphism, has ben widely investigated in its relation with cardiovas-cular and neurodegenerative diseases and longe-vity. ACE gene polymorphism in an inflamation asociated osteoarthritis (OA) patients is not known. Here we have investigated ACE gene polymor-phism in 142 Korean primary kne OA patients and 135 healthy volunters to establish any cli-nical corelates between ACE polymorphism and disease onset age, Kelgren-Lawrence grade and Lequesne's functional index provided additional analysis of the relationship of ACE polymorphism and clinical features of OA. Early onset OA showed significantly higher allele frequency and cariage rate of I than late onset OA. Radio-graphically severe and functionaly por OA showed higher cariage rate of I allele than radiogra-phically mild and functionally god OA, respec-tively. This study first reports ACE gene poly-morphism to be a risk factor for early onset, se-vere form primary knee OA.angiotensin converting enzyme; osteoar-thritis; polymorphism; risk factor
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