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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 110 - 115 (6page)
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The angiotensin converting enzyme (ACE) is a strong candidate gene for myocardial infarction (MI). Insertion-deletion dimorphism intron 16 of this gene has ben inconclusively found to be the ACE gene have been identified and among these, a dimorphism in exon 17, ACE G2350A, has a significant effect on plasma ACE concentra-tions. To ases the value of genotyping the ACE G2350A dimorphism in a geneticaly homogeneous population, we caried out a case-control study of dimorphism G2350A for a putative association with MI among Pakistani nationals. We inves-tigated a sample population of 370 Pakistanis, comprising 163 controls, and 207 patients with clinical diagnosis of acute MI (AMI). ACE G2350A merase chain reaction and restriction endonu-clease analysis. Frequencies of G alleles were 0.68 among controls and 0.72 among AMI patients. The ACE G2350A dimorphism showed no significant association with MI (χ2= 0.90, 2 df, P = 0.64), plasma levels of homocysteine (P = 0.52) or with serum levels of folate (P = 0.29). The results indi-cate that ACE G2350A polymorphism is not as-sociated with risk of myocardial infarction in the Pakistani population investigated here.
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참고문헌 (26)
참고문헌 신청
/ / Distribution of plasma angiotensin I-converting enzymelevels in healthy men relationship to environmental andhormonal parameters corp : 33 ~ 9
/ 1995 / A prospectiveevaluation of an angiotensin-converting-enzyme gene polymorphismand the risk of ischemic heart disease : 706 ~ 11
/ 1995 / Segregationand linkage analysis of serum angiotensin I-convertingenzyme levels evidence for two quantitative-trait loci : 1426 ~ 35
/ 1995 / coronary heart disease : 13 ~ 22
/ 1996 / Identification of new polymorphisms of theangiotensin I-converting enzyme and study oftheir relationship to plasma ACE levels by two-QTL segregationlinkage analysis
/ 1995 / A prospectiveevaluation of an angiotensin-converting-enzyme gene polymorphismand the risk of ischemic heart disease : 706 ~ 11
/ 1995 / Segregationand linkage analysis of serum angiotensin I-convertingenzyme levels evidence for two quantitative-trait loci : 1426 ~ 35
/ 1995 / coronary heart disease : 13 ~ 22
/ 1996 / Identification of new polymorphisms of theangiotensin I-converting enzyme and study oftheir relationship to plasma ACE levels by two-QTL segregationlinkage analysis
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