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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 239 - 245 (7page)
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Unmethylated CpG oligodeoxynucleotides (CpG ODNs) activate immune cells to produce immune mediators. This study demonstrates that in murine macrophage RAW 264.7 cells, CpG ODN-mediated matrix metalloproteinase-9 (MMP-9) expression is regulated at transcriptional level and requires de novo protein synthesis. Inhibition of ERK and p38 MAPK, but not JNK, results in significant decrease of CpG ODN-induced MMP-9 expression. We found that endosomal maturation inhibitors, chloroquine and bafilomycin A, block CpG ODN-induced ERK and p38 MAPK activation and the subsequent MMP-9 expression.
We also observed that CpG ODN induces NF-κB activation and NF-κB is a downstream target of p38 MAPK. Taken together, our data demonstrate that CpG ODN triggers MMP-9 expression via TLR-9 dependent ERK and p38 MAPK activation followed by NF-κB activation.
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참고문헌 (27)
참고문헌 신청
Ahmad-Nejad P / 2002 / CpG ODN-induced MMP-9 expression.245Wagner H. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments
Akira S / 2001 / Toll-like receptors: critical proteins linking innate and acquired immunity 2 : 675 ~ 680
Borregaard N / 1995 / Biosynthesis of granule proteins in normal human bone marrow cells. Gelatinase is a marker of terminal neutrophil differentiation 85 : 812 ~ 817
Chang L / 2001 / Mammalian MAP kinase signalling cas-cades 410 : 37 ~ 40
Chung TW / 2004 / Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activa-tion of ERKs and PI-3K/AKT pathways: involvement of invasive potenti
Akira S / 2001 / Toll-like receptors: critical proteins linking innate and acquired immunity 2 : 675 ~ 680
Borregaard N / 1995 / Biosynthesis of granule proteins in normal human bone marrow cells. Gelatinase is a marker of terminal neutrophil differentiation 85 : 812 ~ 817
Chang L / 2001 / Mammalian MAP kinase signalling cas-cades 410 : 37 ~ 40
Chung TW / 2004 / Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activa-tion of ERKs and PI-3K/AKT pathways: involvement of invasive potenti
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