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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 230 - 238 (9page)
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초록· 키워드
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Colchicine has been shown to regulate the ex-pression of inflammatory gene, but this compound possesses much weaker anti-inflamatory activity. In this study, we synthesized a new colchicine derivative CT20126 and examined its immuno-modulatory property. CT20126 was found to have immunosuppressive effects by inhibiting lympho-cyte proliferation without cytotoxicity and effectively inhibit the transcriptional expression of the inflam-matory genes, iNOS, TNF-α, and IL-1β, in ma-crophages stimulated by LPS. This effect was nearly comparable to that of cyclosporine A. This com-pound also significantly suppressed the production of nitric oxide and Th1-related pro-inflammatory cytokines, IL-1β, TNF-α, and IL-2, with minimal suppression of Th2-related anti-inflammatory cyto-kines IL-4 and IL-10 in the sponge matrix allograft model. Moreover, administration of CT20126 pro-longed the survival of allograft skins from BALB/c mice (H-2d) to the dorsum of C57BL/6 (H-2b) mice. The in vivo immune suppressive e ffects of CT20126 were similar to that of cyclosporine A. These results indicate that this compound may have potential therapeutic value for transplantation rejection and other inflammatory diseases.
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참고문헌 (20)
참고문헌 신청
Abbas AK / 1996 / Functional diversity of helper T-lymphocytes 383 : 787 ~ 793
Benagiano M / 2003 / T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions 100 : 6658 ~ 6663
Calcagni E / 2006 / Stress system activity, innate and T helper cytokines, and susceptibility to immune-related diseases 1069 : 62 ~ 76
Cherwinski H / jimmunol1986;136 / Two types of murine helper T cell clone Definition according to profiles of lymphokine activities and secreted proteins : 2348 ~ 57
Ford HR / transplantation1991;51 / Evidence that production of interleukin 6 within the rejecting allograft coincides with cytotoxic T lymphocyte development : 656 ~ 61
Benagiano M / 2003 / T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions 100 : 6658 ~ 6663
Calcagni E / 2006 / Stress system activity, innate and T helper cytokines, and susceptibility to immune-related diseases 1069 : 62 ~ 76
Cherwinski H / jimmunol1986;136 / Two types of murine helper T cell clone Definition according to profiles of lymphokine activities and secreted proteins : 2348 ~ 57
Ford HR / transplantation1991;51 / Evidence that production of interleukin 6 within the rejecting allograft coincides with cytotoxic T lymphocyte development : 656 ~ 61
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