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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제4호
- 발행연도
- 2009.1
- 수록면
- 424 - 430 (7page)
이용수
초록· 키워드
오류제보하기
IL-10 is an important anti-inflammatory cytokine that
can inhibit the production of many pro-inflammatory
cytokines. Both human and animal studies have shown
that pro-inflammatory cytokines play an important role
in pneumonia and other inflammatory lung diseases. In
the present study, IL-10 knockout (KO) and wild-type
mice were infected with Corynebacterium kutscheri to
determine whether the severity of pathogenesis and whether
protective immunity could be altered in the absence of IL-
10. The survival rate was significantly lower in IL-10 KO
mice than wild-type mice. The number of neutrophils in
bronchoalveolar lavage fluid and blood were found to be
higher in IL-10 KO mice than wild-type mice. IL-10 KO
mice showed greater neutrophil infiltration, excessive
inflammation, and weight-loss compared with wild-type
mice. Furthermore, upregulation of IFN-γ in bronchoalveolar
lavage fluid, and upregulation of MIP-1α and IP-10
mRNA in the lungs of IL-10 KO mice compared with
wild-type mice after C. kutscheri infection were observed.
These results suggest that IL-10 plays an important role
in the anti-inflammatory properties against C. kutscheri
infection, and that lack of IL-10 leads to a more
severe pulmonary inflammatory response. This increased
susceptibility to C. kutscheri pneumonia is at least in part
caused by IL-10 deficiency and severe recruitment of
neutrophils.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Amao, H. / 1995 / Natural and subclinical Corynebacterium kutscheri infection in rats / Lab. Anim. Sci 45 : 11 ~ 14
Amao, H. / 2002 / Detection of Corynebacterium kutscheri from the oral cavity of rats / Exp. Anim 51 : 99 ~ 102
Chmiel, J. F. / 1999 / IL-10 attenuates excessive inflammation in chronic Pseudomonas infection in mice / Am. J. Respir. Crit. Care Med 160 : 2040 ~ 2047
Chmiel, J. F. / 2002 / Prolonged inflammatory response to acute Pseudomonas challenge in interleukin-10 knockout mice / Am. J. Respir. Crit. Care Med 165 : 1176 ~ 1181
Corinti, S. / 2001 / Regulatory activity of autocrine IL-10 on dendritic cell functions / J. Immunol 166 : 4312 ~ 4318
Amao, H. / 2002 / Detection of Corynebacterium kutscheri from the oral cavity of rats / Exp. Anim 51 : 99 ~ 102
Chmiel, J. F. / 1999 / IL-10 attenuates excessive inflammation in chronic Pseudomonas infection in mice / Am. J. Respir. Crit. Care Med 160 : 2040 ~ 2047
Chmiel, J. F. / 2002 / Prolonged inflammatory response to acute Pseudomonas challenge in interleukin-10 knockout mice / Am. J. Respir. Crit. Care Med 165 : 1176 ~ 1181
Corinti, S. / 2001 / Regulatory activity of autocrine IL-10 on dendritic cell functions / J. Immunol 166 : 4312 ~ 4318
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