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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 222 - 229 (8page)
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trans-Resveratrol (t-RVT), a naturally occurring polyphenol found in Polygonum cuspidatum, grape, and red wine, has been reported to have antiinflammatory, cardioprotective, and cancer chemopreventive properties. However antidiabetic effect of t-RVT has not yet been reported. In this study, we show that t-RVT increases glucose uptake in C2C12 myotubes by activating AMP-activated pro - tein kinase (AMPK), uncovering an antidiabetic po - tential of t-RVT for the first time. AMPK plays a central role in the regulation of glucose and lipid metabolism, and hence it is considered a novel therapeutic target for metabolic syndrome such as type 2 diabetes. t-RVT significantly induced glucose uptake in C2C12 cells, via AMPK activation, but not a phosphatidylinositol-3 kinase (PI-3 kinase) signal pathway. The induced glucose uptake was attenuated by pretreatment with a pharmacological inhibitor for AMPK, indicating that the effect of t-RVT primarily depends on AMPK activation. However, in the presence of insulin, t-RVT also po - tentiated the effect of insulin on glucose uptake via AMPK activation, which led to further activation of PI-3 kinase/Akt signal pathway.
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참고문헌 (25)
참고문헌 신청
Ai H / 2002 / Effect of fiber type and nutritional state on AICAR- and contraction-stimulated glucose transport in rat muscle 282 : E1291 ~ E1300
Alessi DR / 1998 / Mechanism of activation and function of protein kinase B 8 : 55 ~ 62
Chen L / 2001 / High-speed counter-current chromatography separation and purification of resveratrol and piceid from Polygonum cuspidatum 907 : 343 ~ 346
Czech MP / 1999 / Signaling mechanisms that regulate glucose transport 274 : 1865 ~ 1868
Das S / 2005 / Pharmacological pre-conditioning with resveratrol role of CREB-dependent Bcl-2 signaling via adenosine A3 receptor activation 288 : H328 ~ H335
Alessi DR / 1998 / Mechanism of activation and function of protein kinase B 8 : 55 ~ 62
Chen L / 2001 / High-speed counter-current chromatography separation and purification of resveratrol and piceid from Polygonum cuspidatum 907 : 343 ~ 346
Czech MP / 1999 / Signaling mechanisms that regulate glucose transport 274 : 1865 ~ 1868
Das S / 2005 / Pharmacological pre-conditioning with resveratrol role of CREB-dependent Bcl-2 signaling via adenosine A3 receptor activation 288 : H328 ~ H335
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