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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 535 - 543 (9page)
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초록· 키워드
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Insufficient intracellular fat oxidation is an important
contributor to aging-related insulin resistance, while
the precise mechanism underlying is unclear. AMP-activated
protein kinase (AMPK) is an important regulator
of intracellular fat oxidation and was evidenced to play
a key role in high-glucose and high-fat induced glucose
intolerance. In the present study, we investigated
whether altered AMPK expression or activity was also
involved in aging-related insulin resistance. Insulin
sensitivity of rats’ skeletal muscles was evaluated
using in-vitro glucose uptake assay. Activity of α subunit
of AMPK (AMPKα ) was evaluated by measuring
the phosphorylation of both AMPKα (P- AMPKα ) and
acetyl-CoA carboxylase (P-ACC), while expression of
AMPKα was assessed by determining the mRNA levels
of AMPKα 1 and AMPKα 2, and protein contents of
AMPKα . Compared with 4-month old rats, 24-month
old rats exhibited obviously impaired insulin sensitivity. At the same time, AMPKα activity significantly
decreased, while AMPKα expression did not
alter during aging. Glucose transporter 4 expression
also decreased in old rats. Compared with 24-month
old rats, administration of the specific activator of
AMPK, 5-aminoimidazole-4-carboxamide riboside
(AICAR), significantly elevated AMPKα activity and
GluT4 expression. Also, aging-related insulin resistance
was significantly ameliorated by AICAR treatment.
In conclusion, aging-related insulin resistance
is associated with impaired AMPKα activity and could
be ameliorated by AICAR, thus indicating a possible
role of AMPK in aging-induced insulin resistance.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
/ 2003 / Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles 94 : 1373 ~ 1379
/ 2003 / diabetes induced by high-fat/high-carbohydrate diets 100 : 10207 ~ 10212
Abu-Elheiga L / 2007 / Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and 542 Exp 39 (4) : 535 ~ 543
Boirie Y / 2001 / Differential insulin sensitivities of glucose, amino acid, and albumin metabolism in elderly men and women 86 ( ) : 638 ~ 644
Calles-Escandon J / 1995 / Basal fat oxidation decreases with aging in women 78 : 266 ~ 271
/ 2003 / diabetes induced by high-fat/high-carbohydrate diets 100 : 10207 ~ 10212
Abu-Elheiga L / 2007 / Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and 542 Exp 39 (4) : 535 ~ 543
Boirie Y / 2001 / Differential insulin sensitivities of glucose, amino acid, and albumin metabolism in elderly men and women 86 ( ) : 638 ~ 644
Calles-Escandon J / 1995 / Basal fat oxidation decreases with aging in women 78 : 266 ~ 271
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