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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 524 - 532 (9page)
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초록· 키워드
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Arginase competitively inhibits nitric oxide synthase (NOS) via use of the common substrate L-arginine.
Arginase II has recently reported as a novel therapeutic target for the treatment of cardiovascular diseases such as atherosclerosis. Here, we demonstrate that piceatannol-3'-O-β-D-glucopyranoside (PG), a potent component of stilbenes, inhibits the activity of arginase I and II prepared from mouse liver and kidney lysates,respectively, in a dose-dependent manner. In human umbilical vein endothelial cells, incubation of PG markedly blocked arginase activity and increased NOx production, as measured by Griess assay. The PG effect was associated with increase of eNOS dimer ratio,although the protein levels of arginase II or eNOS were not changed. Furthermore, isolated mice aortic rings treated with PG showed inhibited arginase activity that resulted in increased nitric oxide (NO) production upto 78%, as measured using 4-amino-5-methylamino-2',7'-difluorescein (DAF-FM) and a decreased superoxide anions up to 63%, as measured using dihydroethidine (DHE) in the intact endothelium. PG showed IC50 value of 11.22 μM and 11.06 μM against arginase I and II, respectively. PG as an arginase inhibitor,therefore, represents a novel molecule for the therapy of cardiovascular diseases derived from endothelial dysfunction and may be used for the design of pharmaceutical compounds.
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참고문헌 (21)
참고문헌 신청
Berkowitz DE / 2003 / Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels / Circulation 108 : 200
Bivalacqua TJ / 2001 / Increased expression of arginase II in human diabetic corpus cavernosum: in diabetic-associated erectile dysfunction / Biochem Biophys Res Commun 283 :
Bivalacqua TJ / 2007 / Endothelial nitric oxide synthase keeps erection regulatory function balance in the penis / Eur Urol 51 : 1732 ~ 1740
Chicoine LG / 2004 / Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells / Am J Physiol Lung Cell Mol Physiol 287 : L60 ~ L68
Choi KH / 2009 / Phosphoinositide-3-kinase is a novel target of piceatannol for inhibiting PDGF-BB-induced proliferation and migration in human aortic smooth muscle cells / C
Bivalacqua TJ / 2001 / Increased expression of arginase II in human diabetic corpus cavernosum: in diabetic-associated erectile dysfunction / Biochem Biophys Res Commun 283 :
Bivalacqua TJ / 2007 / Endothelial nitric oxide synthase keeps erection regulatory function balance in the penis / Eur Urol 51 : 1732 ~ 1740
Chicoine LG / 2004 / Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells / Am J Physiol Lung Cell Mol Physiol 287 : L60 ~ L68
Choi KH / 2009 / Phosphoinositide-3-kinase is a novel target of piceatannol for inhibiting PDGF-BB-induced proliferation and migration in human aortic smooth muscle cells / C
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