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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 584 - 591 (8page)
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초록· 키워드
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In this study, we observed that lysophosphatidylglycerol
(LPG) completely inhibited a formyl peptide receptor
like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic
migration in human phagocytes, such as neutrophils
and monocytes. LPG also dramatically inhibited
IL-1β production by another FPRL1 agonist serum
amyloid A (SAA) in human phagocytes. However,
LPG itself induced intracellular calcium increase and
superoxide anion production in human phagocytes.
Keeping in mind that phagocytes migration and IL-1β
production by FPRL1 are important for the induction
of inflammatory response, our data suggest that LPG
can be regarded as a useful material for the modulation
of inflammatory response induced by FPRL1 activation.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Bae YS / 2001 / Identification of novel chemoattractant peptides for human leukocytes / Blood 97 : 2854 ~ 2862
Bae YS / 2003 / Differential activation of formyl peptide receptor-like 1 by peptide ligands / J Immunol 171 : 6807 ~ 6813
Bae YS / 2004 / Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling / J Immunol 173 : 607 ~ 614
Dahlgren C / 1999 / Respiratory burst in human neutrophils / J Immunol Methods 232 : 3 ~ 14
Dana R / 1998 / Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase / J Biol Chem 273 : 441 ~ 445
Bae YS / 2003 / Differential activation of formyl peptide receptor-like 1 by peptide ligands / J Immunol 171 : 6807 ~ 6813
Bae YS / 2004 / Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling / J Immunol 173 : 607 ~ 614
Dahlgren C / 1999 / Respiratory burst in human neutrophils / J Immunol Methods 232 : 3 ~ 14
Dana R / 1998 / Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase / J Biol Chem 273 : 441 ~ 445
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