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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 325 - 333 (9page)
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Serum amyloid A (SAA) has been regarded as an important
mediator of inflammatory responses. The effect
of several formyl peptide receptor-like 1 (FPRL1)
ligands on the production of IL-8 by SAA was investigated
in human neutrophils. Among the ligands tested,
LL-37 was found to specifically inhibit SAA-induced
IL-8 production in transcriptional and post-transcriptional
levels. Since SAA stimulated IL-8 production
via ERK and p38 MAPK in human neutrophils, we tested
the effect of LL-37 on SAA induction for these two
MAPKs. LL-37 caused a dramatic inhibition of ERK and
p38 MAPK activity, which is induced by SAA. LL-37 was
also found to inhibit SAA-stimulated neutrophil chemotactic
migration. Further, the LL-37-induced inhibitory
effect was mediated by FPRL1. Our findings indicate
that LL-37 is expected to be useful in the inhibition
of SAA signaling and for the development of
drugs against SAA-related inflammatory diseases.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Badolato R / 1994 / Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes / J Exp Med
Bae YS / 2001 / Identification of novel chemoattractant peptides for human leukocytes / Blood 97 : 2854 ~ 2862
Bae YS / 2003 / Differential activation of formyl peptide receptorlike 1 by peptide ligands / J Immunol 71 : 6807 ~ 6813
Chiang N / 2000 / Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation / J Exp Med 191 : 11
Coxon PY / 2003 / MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils / Cell Signal 15 : 993 ~ 1001
Bae YS / 2001 / Identification of novel chemoattractant peptides for human leukocytes / Blood 97 : 2854 ~ 2862
Bae YS / 2003 / Differential activation of formyl peptide receptorlike 1 by peptide ligands / J Immunol 71 : 6807 ~ 6813
Chiang N / 2000 / Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation / J Exp Med 191 : 11
Coxon PY / 2003 / MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils / Cell Signal 15 : 993 ~ 1001
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