지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 130 - 137 (8page)
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초록· 키워드
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Neutrophils play a key role in innate immunity, and the identification of new stimuli that stimulate neutrophil activity is a very important issue. In this study, we identified three novel peptides by screening a synthetic hexapeptide combinatorial library. The identified peptides GMMWAI, MMHWAM, and MMHWFM caused an increase in intracellular Ca2+ in a concentration-dependent manner via phospholipase C activity in human neutrophils. The three peptides acted specifically on neutrophils and monocytes and not on other non-leukocytic cells. As a physiological characteristic of the peptides, we observed that the three peptides induced chemotactic migration of neutrophils as well as stimulated superoxide anion production. Studying receptor specificity, we observed that two of the peptides (GMMWAI and MMHWFM) acted on formyl peptide receptor (FPR)1 while the other peptide (MMHWAM) acted on FPR2. Since the three novel peptides were specific agonists for FPR1 or FPR2, they might be useful tools to study FPR1- or FPR2-mediated immune response and signaling.
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참고문헌 (26)
참고문헌 신청
Aramburu J / 1999 / Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A / Science 285 : 2129 ~ 2133
Badolato R / 1995 / Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway / J Immunol 155
Bae YS / 2004 / Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling / J Immunol 173 : 607 ~ 614
Berridge MJ / 1993 / Inositol trisphosphate and calcium signaling / Nature 361 : 315 ~ 325
Borregaard N / 2010 / Neutrophils, from marrow to microbes / Immunity 33 : 657 ~ 670
Badolato R / 1995 / Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway / J Immunol 155
Bae YS / 2004 / Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling / J Immunol 173 : 607 ~ 614
Berridge MJ / 1993 / Inositol trisphosphate and calcium signaling / Nature 361 : 315 ~ 325
Borregaard N / 2010 / Neutrophils, from marrow to microbes / Immunity 33 : 657 ~ 670
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