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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 171 - 179 (9page)
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초록· 키워드
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Resveratrol is a polyphenolic compound in red wine that has anti-oxidant and cardioprotective effects in animal models. Reactive oxygen species (ROS) and monocyte chemotactic protein-1 (MCP-1) play key roles in foam cell formation and atherosclerosis. We studied LPS-mediated foam cell formation and the effect of resveratrol. Resveratrol pretreatment strongly suppressed LPS-induced foam cell formation. To determine if resveratrol affected the expression of genes that control ROS generation in macrophages, NADPH oxidase 1 (Nox1) was measured. Resveratrol treatment of macrophages inhibited LPS-induced Nox1 expression as well as ROS generation, and also suppressed LPS-induced MCP-1 mRNA and protein expression. We investigated the upstream targets of Nox1 and MCP-1 expression and found that Akt-forkhead transcription factors of the O class (FoxO3a) is an important signaling pathway that regulates both genes. These inhibitory effects of resveratrol on Nox1 expression and MCP-1 production may target to the Akt and FoxO3a signaling pathways.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Adachi Y / 2008 / Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6 / Oncogene 27 : 4921 ~ 4932
Arden KC / 2002 / Regulation of the FoxO family of transcription factors by phosphatidylinositol-3 kinase-activated signaling / Arch Biochem Biophys 403 : 292 ~ 298
Banfi B / 2000 / A mammalian H+channel generated through alternative splicing of the NADPH oxidase homolog NOH-1 / Science 287 : 138 ~ 142
Bedard K / 2007 / The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology / Physiol Rev 87 : 245 ~ 313
Carnevale R / 2007 / LDL are oxidatively modified by platelets via GP91(phox) and accumulate in human monocytes / Faseb J 21 : 927 ~ 934
Arden KC / 2002 / Regulation of the FoxO family of transcription factors by phosphatidylinositol-3 kinase-activated signaling / Arch Biochem Biophys 403 : 292 ~ 298
Banfi B / 2000 / A mammalian H+channel generated through alternative splicing of the NADPH oxidase homolog NOH-1 / Science 287 : 138 ~ 142
Bedard K / 2007 / The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology / Physiol Rev 87 : 245 ~ 313
Carnevale R / 2007 / LDL are oxidatively modified by platelets via GP91(phox) and accumulate in human monocytes / Faseb J 21 : 927 ~ 934
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