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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 19 - 26 (8page)
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DEffects of resveratrol glucosylation on the immunomodulation properties of resveratrol and on the viability of macrophage cells have been studied by using murine macrophage RAW 264.7 cells. Nitric oxide (NO) and interleukin 6 (IL-6) expression in macrophages in vitro were studied after treatment with different concentrations of (E)-resveratrol, (E)-resveratrol 3-O-β-D-glucoside (R-3-G), or (E)-resveratrol 4'-O-β-D-glucoside (R-4'-G). In vitro viability of RAW 264.7 cells after treatment with the aforementioned three compounds was also studied. As demonstrated by macrophage cell viability assays, two different resveratrol monoglucosides, R-3-G and R-4'-G, exhibited 50−80% reduced cytotoxicity in comparison to (E)-resveratrol in A549 and HepG2 cells. Compared to the resveratrol aglycon, both glucosylated resveratrol derivatives positively modulated NO and IL-6 production in macrophages positively via transcriptionally up-regulating IL-6 and iNOS expression. Conjugation of a glucose moiety on resveratrol was found to enhance the immunomodulating activity of resveratrol and the viability of RAW 264.7 cells.
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참고문헌 (22)
참고문헌 신청
Baur JA / 2006 / Therapeutic potential of resveratrol:the in vivo evidence / Nat. Rev. Drug Discov 5 : 493 ~ 506
Bowe CL / 1997 / Design of compounds that increase the absorption of polar molecules / Proc. Natl. Acad. Sci. USA 94 : 12218 ~ 12223
Chan MM / 2000 / Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway / Biochem. Pharm
Detmers PA / 2000 / Deficiency in inducible nitric oxide synthase results in reduced atherosclerosis in apolipoprotein E-deficient mice / J. Immunol 165 : 3430 ~ 3435
Diehl S / 2002 / The two faces of IL-6 on Th1/Th2 differentiation / Mol. Immunol 39 : 531 ~ 536
Bowe CL / 1997 / Design of compounds that increase the absorption of polar molecules / Proc. Natl. Acad. Sci. USA 94 : 12218 ~ 12223
Chan MM / 2000 / Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway / Biochem. Pharm
Detmers PA / 2000 / Deficiency in inducible nitric oxide synthase results in reduced atherosclerosis in apolipoprotein E-deficient mice / J. Immunol 165 : 3430 ~ 3435
Diehl S / 2002 / The two faces of IL-6 on Th1/Th2 differentiation / Mol. Immunol 39 : 531 ~ 536
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