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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 757 - 764 (8page)
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초록· 키워드
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Monocyte chemoattractant protein-1 (MCP1) plays a key role in monocyte/macrophage infiltration to the sub-endothelial space of the blood vessel wall, which is a critical initial step in atherosclerosis. In this study, we examined the intracellular signaling pathway of IL-1β-induced MCP1 expression using various chemical inhibitors. The pretreatment of a phosphatidylcholine (PC)-specific PLC (PC-PLC) inhibitor (D609), PKC inhibitors, or an NF-κB inhibitor completely suppressed the IL-1β-induced MCP1 expression through blocking NF-κB translocation to the nucleus. Pretreatment with inhibitors of tyrosine kinase or PLD partially suppressed MCP1 expression and failed to block nuclear NF-κB translocation. These results suggest that IL-1β induces MCP1 expression through activation of NF-κB via the PC-PLC/PKC signaling pathway.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Baek WK / 2002 / Molecular cloning and characterization of the human budding uninhibited by benomyl (BUB3) promoter / Gene 295 : 117 ~ 123
Boring L / 1998 / Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis / Nature 394 : 894 ~ 897
Chen CC / 2000 / Protein kinase C alpha but not p44/42 mitogen-activated protein kinase, p38, or c-Jun NH(2)-terminal kinase is required for intercellular adhesion molecule-1
Chen YM / 2004 / Dual regulation of tumor necrosis factor-alpha-induced CCL2/monocyte chemoattractant protein-1 expression in vascular smooth muscle cells by nuclear factor-k
Delva E / 2008 / Pemphigus vulgaris IgG-induced desmoglein-3 endocytosis and desmosomal disassembly are mediated by a clathrin- and dynamin-independent mechanism / J Biol Che
Boring L / 1998 / Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis / Nature 394 : 894 ~ 897
Chen CC / 2000 / Protein kinase C alpha but not p44/42 mitogen-activated protein kinase, p38, or c-Jun NH(2)-terminal kinase is required for intercellular adhesion molecule-1
Chen YM / 2004 / Dual regulation of tumor necrosis factor-alpha-induced CCL2/monocyte chemoattractant protein-1 expression in vascular smooth muscle cells by nuclear factor-k
Delva E / 2008 / Pemphigus vulgaris IgG-induced desmoglein-3 endocytosis and desmosomal disassembly are mediated by a clathrin- and dynamin-independent mechanism / J Biol Che
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