지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1 - 14 (14page)
이용수
초록· 키워드
오류제보하기
The pathogenesis of type 2 diabetes mellitus (T2DM) is closely associated with mitochondrial functions in insulinresponsive tissues. The mitochondrial proteome, compared with the mitochondrial genome, which only contains 37 genes in humans, can provide more comprehensive information for thousands of mitochondrial proteins regarding T2DM-associated mitochondrial functions. However, T2DM-associated protein signatures in insulin-responsive tissues are still unclear. Here, we performed extensive proteome profiling of mitochondria from skeletal muscles in nine T2DM patients and nine nondiabetic controls. A comparison of the mitochondrial proteomes identified 335 differentially expressed proteins (DEPs) between T2DM and nondiabetic samples. Functional and network analyses of the DEPs showed that mitochondrial metabolic processes were downregulated and mitochondria-associated ER membrane (MAM) processes were upregulated. Of the DEPs, we selected two (NDUFS3 and COX2) for downregulated oxidative phosphorylation and three (CALR, SORT, and RAB1A) for upregulated calcium and protein transport as representative mitochondrial and MAM processes, respectively, and then confirmed their differential expression in independent mouse and human samples. Therefore, we propose that these five proteins be used as a potential protein profile that is indicative of the dysregulation of mitochondrial functions in T2DM, representing downregulated oxidative phosphorylation and upregulated MAM functions.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Techniques for investigating mitochondrial gene expression
BMB Reports
2020 .01
-
Application of Mitochondrial Transplantation Method in Various Indications
한국생물공학회 학술대회
2024 .09
-
The coordinated regulation of mitochondrial structure and function by Drp1 for mitochondrial quality surveillance
BMB Reports
2019 .01
-
Molecular cross talkamongthecomponentsofthe regulatory machinery of mitochondrial structure and quality control
Experimental and Molecular Medicine
2020 .01
-
microRNA-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor
BMB Reports
2017 .01
-
Emerging perspectives on mitochondrial dysfunction and inflammation in Alzheimer’s disease
BMB Reports
2020 .01
-
Mitochondrial Transplantation as a Novel Treatment Strategy for Tendinopathy
한국생물공학회 학술대회
2023 .04
-
Mitochondrial noncoding RNA transport
BMB Reports
2017 .01
-
K-Means 군집화 알고리즘에 기반한 미토콘드리아의 분류 연구
대한전자공학회 학술대회
2023 .06
-
An experimental approach to study the function of mitochondria in cardiomyopathy
BMB Reports
2015 .01
-
The role of mitochondrial DNA mutation on neurodegenerative diseases
Experimental and Molecular Medicine
2015 .01
-
Mitochondrial dysfunction suppresses p53 expression via calcium-mediated nuclear factor-kB signaling in HCT116 human colorectal carcinoma cells
BMB Reports
2018 .01
-
Robust Isolation of Functional Mitochondria via Ultrasonic Aquatic System
한국생물공학회 학술대회
2024 .09
-
Mitochondrial quality control in intervertebral disc degeneration
Experimental and Molecular Medicine
2021 .07
-
Effects of cisplatin on mitochondrial function and autophagy-related proteins in skeletal muscle of rats
BMB Reports
2021 .11
-
Enhancing Activity of Natural Killer Cell by Mitochondrial Transfer
한국생물공학회 학술대회
2022 .04
-
The role of cell type-specific mitochondrial dysfunction in the pathogenesis of Alzheimer’s disease
BMB Reports
2019 .01
-
노인성 근감소증 개선을 위한 mitochondrial-derived peptide
BT NEWS
2021 .10
-
Exogenous mitochondrial transplantation improves tendon regeneration via modulating apoptosis signaling
한국생물공학회 학술대회
2019 .04
-
Roles of mitochondria in neuronal development
BMB Reports
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0