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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 575 - 580 (6page)
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초록· 키워드
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Cisplatin is widely known as an anti-cancer drug. However,the effects of cisplatin on mitochondrial function and autophagyrelatedproteins levels in the skeletal muscle are unclear. Thepurpose of this study was to investigate the effect of differentdoses of cisplatin on mitochondrial function and autophagy-relatedprotein levels in the skeletal muscle of rats. Eight-weekoldmale Wistar rats (n = 24) were assigned to one of threegroups; the first group was administered a saline placebo (CON,n = 10), and the second and third groups were given 0.1mg/kg body weight (BW) (n = 6), and 0.5 mg/kg BW (n = 8)of cisplatin, respectively. The group that had been administered0.5 mg cisplatin exhibited a reduced BW, skeletal muscletissue weight, and mitochondrial function and upregulated levelsof autophagy-related proteins, including LC3II, Beclin 1, andBNIP3. Moreover, this group had a high LC3 II/I ratio in theskeletal muscle; i.e., the administration of a high dose of cisplatindecreased the muscle mass and mitochondrial functionand increased the levels of autophagy-related proteins. Theseresults, thus, suggest that reducing mitochondrial dysfunctionand autophagy pathways may be important for preventing skeletalmuscle atrophy following cisplatin administration.
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참고문헌 (39)
참고문헌 신청
Frezza M / 2010 / Novel metals and metal complexes as platforms for cancer therapy / Curr Pharm Des 16:1813~1825
Kelland L / 2007 / The resurgence of platinum-based cancer chemotherapy / Nat Rev Cancer 7:573~584
정의택 / 2020 / Overcoming Multidrug Resistance by Activating Unfolded Protein Response of the Endoplasmic Reticulum in Cisplatin-Resistant A2780/CisR Ovarian Cancer Cells / BMB Reports 53(2):88~93
진유진 / 2019 / Inhibition of p90RSK activation sensitizes triple-negative breast cancer cells to cisplatin by inhibiting proliferation, migration and EMT / BMB Reports 52(12):706~711
Conte E / 2020 / Cisplatin-induced skeletal muscle dysfunction : mechanisms and counteracting therapeutic strategies / Int J Mol Sci 21:1242
Kelland L / 2007 / The resurgence of platinum-based cancer chemotherapy / Nat Rev Cancer 7:573~584
정의택 / 2020 / Overcoming Multidrug Resistance by Activating Unfolded Protein Response of the Endoplasmic Reticulum in Cisplatin-Resistant A2780/CisR Ovarian Cancer Cells / BMB Reports 53(2):88~93
진유진 / 2019 / Inhibition of p90RSK activation sensitizes triple-negative breast cancer cells to cisplatin by inhibiting proliferation, migration and EMT / BMB Reports 52(12):706~711
Conte E / 2020 / Cisplatin-induced skeletal muscle dysfunction : mechanisms and counteracting therapeutic strategies / Int J Mol Sci 21:1242
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