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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Recently the pathological actions of CagA of Helicobacter pylori (H. pylori) on gastric epithelial cells have been reported. CagA is directly injected into the host cytoplasm and undergoes tyrosine phosphorylation in the cells. In addition, translocated CagA forms a physical complex with SHP-2. There are two major CagA subtypes according to the amino acid sequence in the 3' region of CagA; i) the East Asian type (A-B-D of EPIYA motifs) and ii) the Western type (A-B-C of EPIYA motifs). Repeated EPIYA motifs in the 3' region of CagA are involved in the interaction with SHP-2. The East Asian type conferred stronger SHP-2 binding activity than the Western type of CagA. Here we analyzed the amino acid sequences of the SHP-2 binding site of cagA gene in H. pylori, and investigated whether there is any relationship between the diversities of cagA and the disease outcome in Korea. Most of Korean H. pylori strains showed A-B-D motifs (the East Asian type), and only one strain showed A-B-B-D motifs. In Korea, the incidence of atrophic gastritis and gastric cancer is significantly high compared with Western countries. The high frequency of the East Asian type CagA among Korean H. pylori strains would be involved in increasing the risk of gastric cancer in Korean populations.
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참고문헌 (21)
참고문헌 신청
Argent, R. H., M. Kidd, R. J. Owen, R. J. Thomas, M. C. Limb and J. C. Atherton. 2004. Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori. Gastroenterology 127, 514-523.
Atherton, J. C., P. Cao, R. M. Peek Jr, Tummuru R, M. J. Blaser and T. L. Cover. 1995. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J. Biol. Chem. 27
Azuma, T. 2004. Helicobacter pylori CagA protein variation associated with gastric cancer in Asia. J. Gastroenterol. 39, 97-103.
Azuma, T., A. Yamakawa, S. Yamazaki, K. Fukuta, M, Ohtani, Y. Ito, M. Doju, Y. Yamazaki and M. Kuriyama. 2002. Correalation between variation of the 3'region of the cagA gene in Helicobacetr pylori and disease outcome in Japan. Journal Infect. Dis. 186, 1
Azuma, T., S. Yamazaki, A. Yamakawa, M. Ohtani, A. Muramatsu, H. Suto, Y. Ito, M. Doju, Y. Yamazaki, M. Kuriyama, Y. Keida, H. Higashi and M. Hatakeyama. 2004. Association between diversity in the Src homology 2 domain-containing tyrosine phosphatase bind
Atherton, J. C., P. Cao, R. M. Peek Jr, Tummuru R, M. J. Blaser and T. L. Cover. 1995. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J. Biol. Chem. 27
Azuma, T. 2004. Helicobacter pylori CagA protein variation associated with gastric cancer in Asia. J. Gastroenterol. 39, 97-103.
Azuma, T., A. Yamakawa, S. Yamazaki, K. Fukuta, M, Ohtani, Y. Ito, M. Doju, Y. Yamazaki and M. Kuriyama. 2002. Correalation between variation of the 3'region of the cagA gene in Helicobacetr pylori and disease outcome in Japan. Journal Infect. Dis. 186, 1
Azuma, T., S. Yamazaki, A. Yamakawa, M. Ohtani, A. Muramatsu, H. Suto, Y. Ito, M. Doju, Y. Yamazaki, M. Kuriyama, Y. Keida, H. Higashi and M. Hatakeyama. 2004. Association between diversity in the Src homology 2 domain-containing tyrosine phosphatase bind
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UCI(KEPA) : I410-ECN-0101-2009-470-015375890