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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 820 - 827 (8page)
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Present study demonstrated that fibrillar β-amyloid peptide (fAβ1-42) induced ATP release, which in turn ac-tivated NADPH oxidase via the P2X7 receptor (P2X7R). Reactive oxygen species (ROS) production in fAβ1-42- treated microglia appeared to require Ca2+ influx from extracellular sources, because ROS generation was abolished to control levels in the absence of ex-tracellular Ca2+. Considering previous observation of superoxide generation by Ca2+ influx through P2X7R in fAβ-stimulated microglia might be mediated by ATP re-leased from the microglia. We therefore examined whether fAβ1-42-induced Ca2+influx was mediated through P2X7R activation. In serial experiments, we found that microglial pretreatment with the P2X7R an-tagonists Pyridoxal-phosphate-6-azophenyl-2',4'- di-sulfonate (100 M) or oxidized ATP (100 M) inhibited fAβ-induced Ca2+ influx and reduced ROS generation to basal levels. Furthermore, ATP efflux from fAβ1-42- stimulated microglia was observed, and apyrase treat-ment decreased the generation of ROS. These findings provide conclusive evidence that fAβ-stimulated ROS generation in microglial cells is regulated by ATP re-leased from the microglia in an autocrine manner.
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참고문헌 (21)
참고문헌 신청
Bianca VD / 1999 / β-amyloid activates the O2ㆍforming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzhei
Boulay F / fasebj1993 / Activation of neutrophil leukocytes : 1004 ~ 10
Burnstock G / 2007 / Physiology and pathophysiology of purinergic neurotransmission 87 : 659 ~ 797
DeLeo FR / 1996 / Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins 60 : 677 ~ 691
Dichmann S / 2000 / Adeno-sine triphosphate-induced oxygen radical production and CD11b up-regulation: Ca++mobilization and actin reorgani-zation in human eosinophils 95 ( )
Boulay F / fasebj1993 / Activation of neutrophil leukocytes : 1004 ~ 10
Burnstock G / 2007 / Physiology and pathophysiology of purinergic neurotransmission 87 : 659 ~ 797
DeLeo FR / 1996 / Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins 60 : 677 ~ 691
Dichmann S / 2000 / Adeno-sine triphosphate-induced oxygen radical production and CD11b up-regulation: Ca++mobilization and actin reorgani-zation in human eosinophils 95 ( )
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