지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 722 - 732 (11page)
이용수
초록· 키워드
오류제보하기
A transprogram human telomerase reverse transcriptase (hTERT) RNA was previously suggested as a useful agent for tumor-targeted gene therapy. In this study, we evaluated in vivo function of the hTERT-targeting trans-splicing ribozymes by employing the molecular analysis of expression level of genes affected by the ribozyme delivery into peritoneal carcinomatosis mice model. To this effect, we constructed adenoviral vector four-fold reduction in the level of hTERT RNA was ob-served in tumor nodules by the systemic infection of the ribozyme-encoding virus. Such hTERT RNA knock-down in vivo induced changes in the global gene ex-pression profile, including the suppresion of specific genes associated with anti-apoptosis including bcl2, and genes for angiogenesis and metastasis. In addi-tion, specific trans-splicing reaction with the targeted peritoneal carcinomatosis in mice by systemic deliv-ery of the ribozyme. In conclusion, this study demon-strates that an hTERT-specific RNA replacement ap-proach using trans-splicing ribozyme represents a po-tential modality to treat cancer.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
/ 2003 / Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707 23 : 4598 ~ 4610
/ 2007 / 732 Exp 39 (6) : 722 ~ 732
Been MD / / One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing : 207 ~ 16
Del Bufalo D / 2005 / Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function 12 : 1429 ~ 1438
Du ZX / 2006 / Antisurvivin oligonucleotides inhibit growth and induce apoptosis in human meduallary thyroid carcinoma cells 38 : 230 ~ 240
/ 2007 / 732 Exp 39 (6) : 722 ~ 732
Been MD / / One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing : 207 ~ 16
Del Bufalo D / 2005 / Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function 12 : 1429 ~ 1438
Du ZX / 2006 / Antisurvivin oligonucleotides inhibit growth and induce apoptosis in human meduallary thyroid carcinoma cells 38 : 230 ~ 240
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Specificity of Intracellular Trans-Splicing Reaction by hTERT-Targeting Group I Intron
Genomics & informatics
2005 .01
-
Cancer Cell Targeting with Mouse TERT-Specific Group I Intron of Tetrahymena thermophila
Journal of Microbiology and Biotechnology
2009 .01
-
In Vivo Target RNA Specificity of Trans-Splicing Phenomena by the Group I Intron
Genomics & informatics
2008 .01
-
Cancer-Specific Induction of Adenoviral E1A Expression by Group I Intron-Based Trans-Splicing Ribozyme
Journal of Microbiology and Biotechnology
2012 .01
-
An RNA Mapping Strategy to Identify Ribozyme-Accessible Sites on the Catalytic Subunit of Mouse Telomerase
Genomics & informatics
2007 .01
-
Re-Engineering of Carcinoembryonic Antigen RNA with the GroupIntron of Tetrahymena thermophila by Targeted Trans-Splicing
Journal of Microbiology and Biotechnology
2005 .01
-
Tetrahymena thermophila의 group Ⅰ intron에 의한 trans-splicing 반응에 미치는 표적 RNA 구조의 영향분석
미생물학회지
1999 .09
-
Functional Modification of a Specific RNA with Targeted Trans-Splicing
Genomics & informatics
2004 .01
-
RNA Mapping of Mutant Myotonic Dystrophy Protein Kinase 3'-Untranslated Region Transcripts
Genomics & informatics
2009 .01
-
Control of RNA Stability for Gene Function
한국미생물학회 학술대회논문집
2009 .05
-
C형 간염바이러스(HCV) 유전체를 특이적으로 변형할 수 있는 Trans-Splicing Aptazyme 발굴
미생물학회지
2008 .09
-
RNA cleavage activity of DNA enzyme and Hammerhead ribozyme targeted to TEL/AML1 fusion gene
한국생명과학회 심포지움
2005 .04
-
A Clue for Prebiotic Era : Cross - Catalytic Replication of an RNA Ligase Ribozyme
한국생명과학회 심포지움
2004 .10
-
Comparative Analysis of Intracellular Trans-Splicing Ribozyme Activity Against Hepatitis C Virus Internal Ribosome Entry Site
The Journal of Microbiology
2004 .12
-
Pathogenic diversity of RNA variants and RNA variation-associated factors in cancer development
Experimental and Molecular Medicine
2020 .01
-
Hammerhead Ribozymes Reduce the Expression of HBV X gene in Mammalian Cells
한국동물학회 학술대회
1997 .01
-
인간 파필로마 바이러스 E6/E7에 의한 Telomerase 활성
대한임상검사과학회지
2007 .01
-
Cloning된 효모의 RNAI 유전자의 특성에 관하여
한국어병학회지
1993 .01
-
In vitro Synthesis of Ribonucleic Acids by T7 RNA Polymerase That was Fast Purified with a Modified Procedure
생명과학회지
2005 .10
-
Alternative Splicing and Its Impact as a Cancer Diagnostic Marker
Genomics & informatics
2012 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0