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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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The Wnt/β-catenin pathway has a role in osteoblast differentiation and bone formation. We screened 100 plant extracts and identified an extract from Euodia sutchuenensis Dode (ESD) leaf and young branch as an effective activator of the Wnt/β-cateninpathway. ESD extract increased β-catenin levels and β-catenin nuclear accumulation in murine primary osteoblasts. The ESD extract also increased mRNA levels of osteoblast markers, including RUNX2, BMP2 and COL1A1, and enhanced alkaline phosphatase (ALP) activity in murine primary osteoblasts. Both ESD extract-induced β-catenin increment and ALP activation were abolished by β-catenin knockdown, confirming that the nt/β-catenin pathway functions in osteoblast differentiation. ESD extract enhanced terminal osteoblast differentiation as shown by staining with Alizarin Red S and significantly increased murine calvarial bone thickness. This study shows that ESD extract stimulates osteoblast differentiation via the Wnt/β-catenin pathway and enhances murine calvarial bone formation ex vivo.
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참고문헌 (26)
참고문헌 신청
Baron R / 2006 / Wnt signaling : a key regulator of bone mass / Curr Top Dev Biol 76 : 103 ~ 127
Cheung AM / 2004 / Canadian Task Force on Preventive Health Care. Prevention of osteoporosis and osteoporotic fractures in postmenopausal women: recommendation statement from
Garrett IR / 2007 / Anabolic agents and the bone morphogenetic protein pathway / Curr Top Dev Biol 78 : 127 ~ 171
Gaur T / 2005 / Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression / J Biol Chem 280 : 33132 ~ 33140
Guo AJ / 2011 / Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway / J Biol Chem 286 : 27882 ~ 27
Cheung AM / 2004 / Canadian Task Force on Preventive Health Care. Prevention of osteoporosis and osteoporotic fractures in postmenopausal women: recommendation statement from
Garrett IR / 2007 / Anabolic agents and the bone morphogenetic protein pathway / Curr Top Dev Biol 78 : 127 ~ 171
Gaur T / 2005 / Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression / J Biol Chem 280 : 33132 ~ 33140
Guo AJ / 2011 / Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway / J Biol Chem 286 : 27882 ~ 27
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