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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 97 - 102 (6page)
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Patients with inflammatory bone disease or cancer exhibit an increased risk of fractures and delayed bone healing. The S100A4 protein is a member of the calcium-binding S100 protein family, which is abundantly expressed in inflammatory diseases and cancers. We investigated the effects of extracellular S100A4 on osteoblasts, which are cells responsible for bone formation. Treating primary calvarial osteoblasts with recombinant S100A4 resulted in matrix mineralization reductions. The expression of osteoblast marker genes including osteocalcin and osterix was also suppressed. Interestingly, S100A4 stimulated the nuclear factor-kappaB (NF-κB) signaling pathway in osteoblasts. More importantly, the ex vivo organ culture of mouse calvariae with recombinant S100A4 decreased the expression levels of osteocalcin, supporting the results of our in vitro experiments. This suggests that extracellular S100A4 is important for the regulation of bone formation by activating the NF-κB signaling pathway in osteoblasts.
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참고문헌 (23)
참고문헌 신청
Boye K / 2010 / S100A4 and metastasis: a small actor playing many roles / Am J Pathol 176 : 528 ~ 535
Chang J / 2009 / Inhibition of osteoblastic bone formation by nuclear factor-kappaB / Nat Med 15 : 682 ~ 689
Chang J / 2013 / NF-kappaB inhibits osteogenic differentiation of mesenchymal stem cells by promoting beta-catenin degradation / Proc Natl Acad Sci U S A 110 : 9469 ~ 9474
Emberley ED / 2004 / S100 proteins and their influence on pro-survival pathways in cancer / Biochem Cell Biol 82 : 508 ~ 515
Erlandss
Chang J / 2009 / Inhibition of osteoblastic bone formation by nuclear factor-kappaB / Nat Med 15 : 682 ~ 689
Chang J / 2013 / NF-kappaB inhibits osteogenic differentiation of mesenchymal stem cells by promoting beta-catenin degradation / Proc Natl Acad Sci U S A 110 : 9469 ~ 9474
Emberley ED / 2004 / S100 proteins and their influence on pro-survival pathways in cancer / Biochem Cell Biol 82 : 508 ~ 515
Erlandss
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