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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 525 - 530 (6page)
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Activation of the Wnt/β-catenin pathway plays a pathogenic role in age-related macular degeneration (AMD) and is thus a potential target for the development of therapeutics for this disease. Here, we demonstrated that Wnt5a antagonized β-catenin response transcription (CRT) induced with Wnt3a by promoting β-catenin phosphorylation at Ser33/Ser37/Thr41 and its subsequent degradation in human retinal pigment epithelial (RPE) cells. Wnt5a decreased the levels of vascular endothelial growth factor (VEGF), tumor necrosis factor-α (TNF-α), and nuclear factor-κB (NF-κB), which was up-regulated by Wnt3a. Furthermore, Wnt5a increased E-cadherin expression and decreased cell migration by down-regulating Snail expression, thereby abrogating the Wnt3a-induced epithelial-mesenchymal transition (EMT) in human RPE cells. Our findings suggest that Wnt5a suppresses the pathogenic effects of canonical Wnt signaling in human RPE cells by promoting β-catenin phosphorylation and degradation. Therefore, Wnt5a has significant therapeutic potential for the treatment of AMD.
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참고문헌 (27)
참고문헌 신청
[학술지(정기간행물)
Aberle H / 1997 / β-Catenin is a target for the ubiquitin-proteasome pathway / EMBO J 16 : 3797 ~ 3804
Augustin AJ / 2009 / Inflammation and the pathogenesis of age-related macular degeneration / Expert Opin Ther Targets 13 : 641 ~ 651
Beatty S / 2000 / The role of oxidative stress in the pathogenesis of age-related macular degeneration / Surv Ophthalmol 45 : 115 ~ 134
Bhutto I / 2012 / Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris
Aberle H / 1997 / β-Catenin is a target for the ubiquitin-proteasome pathway / EMBO J 16 : 3797 ~ 3804
Augustin AJ / 2009 / Inflammation and the pathogenesis of age-related macular degeneration / Expert Opin Ther Targets 13 : 641 ~ 651
Beatty S / 2000 / The role of oxidative stress in the pathogenesis of age-related macular degeneration / Surv Ophthalmol 45 : 115 ~ 134
Bhutto I / 2012 / Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris
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