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- 2015.1
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Disturbances in the sleep–wake cycle and circadian rhythms are common symptoms of Alzheimer Disease (AD), and they have generally been considered as late consequences of the neurodegenerative processes. Recent evidence demonstrates that sleep–wake and circadian disruption often occur early in the course of the disease and may even precede the development of cognitive symptoms. Furthermore, the sleep–wake cycle appears to regulate levels of the pathogenic amyloid-beta peptide in the brain, and manipulating sleep can influence AD-related pathology in mouse models via multiple mechanisms. Finally, the circadian clock system, which controls the sleep–wake cycle and other diurnal oscillations in mice and humans, may also have a role in the neurodegenerative process. In this review, we examine the current literature related to the mechanisms by which sleep and circadian rhythms might impact AD pathogenesis, and we discuss potential therapeutic strategies targeting these systems for the prevention of AD.
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참고문헌 (25)
참고문헌 신청
Ancoli-Israel S / 2003 / The role of actigraphy in the study of sleep and circadian rhythms / Sleep 26 : 342 ~ 392
Duncan MJ / 2012 / Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer's disease / Exp Neurol
Hahn EA / 2014 / A change in sleep pattern may predict Alzheimer Disease / Am J Geriatr Psychiatry 22 : 1262 ~ 1271
Hatfield CF / 2004 / Disrupted daily activity/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer's dementia / Brain 127 : 1061 ~
Ju YE / 2013 / Sleep quality and preclinical Alzheimer disease / JAMA Neurol 70 : 587 ~ 593
Duncan MJ / 2012 / Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer's disease / Exp Neurol
Hahn EA / 2014 / A change in sleep pattern may predict Alzheimer Disease / Am J Geriatr Psychiatry 22 : 1262 ~ 1271
Hatfield CF / 2004 / Disrupted daily activity/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer's dementia / Brain 127 : 1061 ~
Ju YE / 2013 / Sleep quality and preclinical Alzheimer disease / JAMA Neurol 70 : 587 ~ 593
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