지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 687 - 694 (8page)
이용수
초록· 키워드
오류제보하기
Legionella bacterium, an intracellular pathogen of
mononuclear phagocytes, causes acute fatal pneumonia,
especially in patients with impaired cellular immune
responses. Until recently, however, the toll-like
receptor (TLR) engagement of bacterial proteins derived
from Legionella is uncertain. We previously
showed that a 19-kDa highly conserved peptidoglycan-
associated lipoprotein (PAL) of Legionella pneumophila
induced the PAL-specific B cell and T cell responses
in mice. In this study, we observed that the
rPAL antigen of L. pneumophila, as an effector molecule,
activated murine macrophages via TLR2 and produced
proinflammatory cytokines such as IL-6 and
TNF-α. In both BALB/c and TLR4-deficient C3H/HeJ
mice, pretreatment of macrophages with anti-TLR2
mAb showed severely impaired cytokine production in
response to the rPAL. In addition, in vitro the rPAL treatment
increased the cell surface expression of CD40,
CD80, CD86 and MHC I/II molecules. We further showed
that the synthetic CpG-oligodeoxynucleotides (CpG
ODN) coadministered with the rPAL enhanced IL-12
and IL-6 production and expression of CD40, CD80 and
MHC II compared to the rPAL treatment alone. In conclusions,
these results indicate that Legionella PAL
might activate macrophages via a TLR2-dependent
mechanism which thus induce cytokine production
and expression of costimulatory and MHC molecules.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Akamine M / 2005 / Differential roles of Toll-like receptors 2 and 4 in in vitro responses of macrophages to Legionella pneumophila / Infect Immun 73 : 352 ~ 361
Akira S / 2001 / Toll-like receptors: critical proteins linking innate and acquired immunity / Nat Immunol 2 : 675 ~ 680
Archer KA / 2006 / MyD88-dependent responses involving toll-like receptor 2 are important for protection and clearance of Legionella pneumophila in a mouse model of Legionnai
Barton GM / 2002 / Control of adaptive immune responses by Toll-like receptors / Curr Opin Immunol 14 : 380 ~ 383
Braedel-Ruoff S / 2005 / Legionella pneumophila mediated activation of dendritic cells involves CD14 and TLR2 / J Endotoxin Res 11 : 89 ~ 96
Akira S / 2001 / Toll-like receptors: critical proteins linking innate and acquired immunity / Nat Immunol 2 : 675 ~ 680
Archer KA / 2006 / MyD88-dependent responses involving toll-like receptor 2 are important for protection and clearance of Legionella pneumophila in a mouse model of Legionnai
Barton GM / 2002 / Control of adaptive immune responses by Toll-like receptors / Curr Opin Immunol 14 : 380 ~ 383
Braedel-Ruoff S / 2005 / Legionella pneumophila mediated activation of dendritic cells involves CD14 and TLR2 / J Endotoxin Res 11 : 89 ~ 96
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