지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 678 - 685 (8page)
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초록· 키워드
오류제보하기
In spite of the importance of phospholipase D (PLD) in
cell proliferation and tumorigenesis, little is known
about the molecules regulating PLD expression. Thus,
identification of small molecules inhibiting PLD expression
would be an important advance for PLDmediated
physiology. We examined one such here, denoted
“Triptolide”, which was identified in a chemical
screen for inhibitors of PLD expression using cell assay
system based on measurement of PLD promoter
activity. Triptolide significantly suppressed the expression
of both PLD1 and PLD2 with sub-μM potency
in MDA-MB-231 breast cancer cells as analyzed by promoter
assay and RT-PCR. Moreover, triptolide abolished
the protein level of PLD in a time and dose-dependent
manner. Triptolide-induced PLD1 downregulation
was also observed in all the cancer cells examined,
suggesting a general phenomenon detected in
various cancer cells. Decrease of PLD expression by
triptolide suppressed both basal and PMA-induced
PLD activity. In addition, triptolide inhibited activation
of NFκB which increased PLD1 expression. Ultimately,
downregulation of PLD by triptolide inhibited proliferation
of breast cancer cells. Taken together, we
demonstrate that triptolide suppresses the expression
of PLD via inhibition of NFκB activation and then decreases
cell proliferation.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Ahn BH / 2003 / Transmodulation between phospholipase D and c-Src enhances cell proliferation / Mol Cell Biol 23 : 3103 ~ 3115
Buchanan FG / 2005 / Requirement of phospholipase D1 activity in H-RasV12-induced transformation / Proc Natl Acad Sci USA 102 : 1638 ~ 1642
Chang WT / 2001 / Triptolide and chemotherapy cooperate in tumor cell apoptosis. A role for the p53 pathway / J Biol Chem 276 : 2221 ~ 2227
Chen BJ / 2001 / Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F / Leuk Lymphoma 42 : 253 ~ 265
Chen Y / 2003 / Phospholipase D confers rapamycin resistance in human breast cancer cells / Oncogene 22 : 3937 ~ 3942
Buchanan FG / 2005 / Requirement of phospholipase D1 activity in H-RasV12-induced transformation / Proc Natl Acad Sci USA 102 : 1638 ~ 1642
Chang WT / 2001 / Triptolide and chemotherapy cooperate in tumor cell apoptosis. A role for the p53 pathway / J Biol Chem 276 : 2221 ~ 2227
Chen BJ / 2001 / Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F / Leuk Lymphoma 42 : 253 ~ 265
Chen Y / 2003 / Phospholipase D confers rapamycin resistance in human breast cancer cells / Oncogene 22 : 3937 ~ 3942
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세포사멸에서 Phospholipase D 동위효소의 기능적 역할
생명과학회지
2014 .12
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Phospholipase D inhibitor enhances radiosensitivity of breast cancer cells
Experimental and Molecular Medicine
2013 .01
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Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression
Experimental and Molecular Medicine
2009 .01
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Activation of Phospholipase D2 through Phosphorylation of Tyrosine-470 in Antigen-stimulated Mast Cells
생명과학회지
2005 .06
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Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells
Experimental and Molecular Medicine
2006 .01
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Anti-apoptotic role of phospholipase D isozymes in the glutamate-induced cell death
Experimental and Molecular Medicine
2003 .01
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Triptolide inhibits ovarian cancer cell invasion by repression of matrix metalloproteinase 7 and 19 and upregulation of E-cadherin
Experimental and Molecular Medicine
2012 .01
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Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid
Experimental and Molecular Medicine
2014 .01
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Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells
Experimental and Molecular Medicine
2014 .01
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Rebamipide-induced downregulation of phospholipase D inhibits inflammation and proliferation in gastric cancer cells
Experimental and Molecular Medicine
2010 .01
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Phospholipase D Activity is Elevated in Hepatitis C Virus Core Protein-Transformed NIH 3T3 Mouse Fibroblast Cells
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2003 .10
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Involvement of protein kinase C pathway in UVC-stimulated phospholipase D2 activity in Vero 76 cells
Experimental and Molecular Medicine
2005 .01
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Phosphorylation of phospholipase D1 and the modulation of its interaction with RhoA by cAMP-dependent protein kinase
Experimental and Molecular Medicine
2004 .01
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Role of phospholipase D1 in glucose-induced insulin secretion in pancreatic β cells
Experimental and Molecular Medicine
2010 .01
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인간 교세포주에서 CoCl₂에 의한 phospholipase D의 조절기전
생명과학회지
2006 .07
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The hydrophobic amino acids involved in the interdomain association of phospholipase D1 regulate the shuttling of phospholipase D1 from vesicular organelles into the nucleus
Experimental and Molecular Medicine
2012 .01
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PLD를 이용한 Zn0.9757Fe0.03O 박막의 결정학적 및 자기적 특성 연구
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2005 .12
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호중구에서 phospholipase D의 활성에 대한 protein kinase G의 영향
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2003 .12
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PLD 법으로 제조된 Co - doped TiO₂ 박막의 자기 특성 연구
한국자기학회 학술연구발표회 논문개요집
2002 .12
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