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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 717 - 727 (11page)
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초록· 키워드
오류제보하기
Triptolide, a diterpenoid triepoxide from the traditional
Chinese medicinal herb Tripterygium wilfordii Hook. f.,
is a potential treatment for autoimmune diseases as
well a possible anti-tumor agent. It inhibits proliferation
of coloretal cancer cells in vitro and in vivo.
In this study, its ability to block progress of colitis to
colon cancer, and its molecular mechanism of action
are investigated. A mouse model for colitis-induced
colorectal cancer was used to test the effect of triptolide
on cancer progression. Treatment of mice with triptolide
decreased the incidence of colon cancer formation,
and increased survival rate. Moreover, triptolide
decreased the incidence of tumors in nude mice inoculated
with cultured colon cancer cells dose-dependently.
In vitro, triptolide inhibited the proliferation, migration
and colony formation of colon cancer cells.
Secretion of IL6 and levels of JAK1, IL6R and phosphorylated
STAT3 were all reduced by triptolide
treatment. Triptolide prohibited Rac1 activity and
blocked cyclin D1 and CDK4 expression, leading to G1
arrest. Triptolide interrupted the IL6R-JAK/STAT pathway
that is crucial for cell proliferation, survival, and
inflammation. This suggests that triptolide might be a
candidate for prevention of colitis induced colon cancer
because it reduces inflammation and prevents tumor
formation and development.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Atreya R / 2001 / Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and e
Atreya R / 2005a / Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer / Clin Rev Allergy Immunol 28 : 187 ~ 196
Atreya R / 2005b / Signaling molecules: the pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal inflammation and in colonic cancer / Curr Drug Targets 9
Belluco C / 2000 / Interleukin-6 blood level is associated with circulating carcinoembryonic antigen and prognosis in patients with colorectal cancer / Ann Surg Oncol 7 : 133
Brinker AM / 2007 / Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae) / Phytochemistry 68 : 732 ~ 766
Atreya R / 2005a / Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer / Clin Rev Allergy Immunol 28 : 187 ~ 196
Atreya R / 2005b / Signaling molecules: the pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal inflammation and in colonic cancer / Curr Drug Targets 9
Belluco C / 2000 / Interleukin-6 blood level is associated with circulating carcinoembryonic antigen and prognosis in patients with colorectal cancer / Ann Surg Oncol 7 : 133
Brinker AM / 2007 / Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae) / Phytochemistry 68 : 732 ~ 766
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Triptolide-induced suppression of phospholipase D expression inhibits proliferation of MDA-MB-231 breast cancer cells
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