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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 555 - 564 (10page)
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초록· 키워드
오류제보하기
Rebamipide a gastroprotective drug, is clinically used for the treatment of gastric ulcers and gastritis, but its actions on gastric cancer are not clearly understood.
Phospholipase D (PLD) is overexpressed in various types of cancer tissues and has been implicated as a critical factor in inflammation and carcinogenesis.
However, whether rebamipide is involved in the regulation of PLD in gastric cancer cells is not known. In this study, we showed that rebamipide significantly suppressed the expression of both PLD1 and PLD2 at a transcriptional level in AGS and MKN-1 gastric cancer cells. Downregulation of PLD expression by rebamipide inhibited its enzymatic activity. In addition,rebamipide inhibited the transactivation of nuclear factor kappa B (NFκB), which increased PLD1 expression.
Rebamipide or PLD knockdown significantly suppressed the expression of genes involved in inflammation and proliferation and inhibited the proliferation of gastric cancer cells. In conclusion, rebamipide-induced downregulation of PLD may contribute to the inhibition of inflammation and proliferation in gastric cancer.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Ahn BH / 2003 / Transmodulation between Phospholipase D and c-Src Enhances Cell Proliferation / Mol Cell Biol 23 : 3103 ~ 3115
Aihara M / 1998 / Molecular analysis of suppression of interleukin-8 production by rebamipide in Helicobacter pylori-stimulated gastric cancer cell lines / Dig Dis Sci 43 : 1
Arakawa T / 1998 / Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing / Dig Dis Sci 43 : 5S ~ 13S
Arakawa T / 2005 / 15th anniversary of rebamipide: looking ahead to the new mechanisms and new applications / Dig Dis Sci 50 : S3 ~ S11
Dong Woo Kang / 2009 / Triptolide-induced suppression of phospholipase D expression inhibits proliferation of MDA-MB-231 breast cancer cells / Experimental and Molecular Medi
Aihara M / 1998 / Molecular analysis of suppression of interleukin-8 production by rebamipide in Helicobacter pylori-stimulated gastric cancer cell lines / Dig Dis Sci 43 : 1
Arakawa T / 1998 / Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing / Dig Dis Sci 43 : 5S ~ 13S
Arakawa T / 2005 / 15th anniversary of rebamipide: looking ahead to the new mechanisms and new applications / Dig Dis Sci 50 : S3 ~ S11
Dong Woo Kang / 2009 / Triptolide-induced suppression of phospholipase D expression inhibits proliferation of MDA-MB-231 breast cancer cells / Experimental and Molecular Medi
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