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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 418 - 426 (9page)
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초록· 키워드
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Osteonecrosis of the femoral head (ONFH) is known as death of the cellular portion of the femoral head due to an interruption in the vascular supply. The underlying pathophysiology regarding bone cell death remains uncertain. Recently, several studies have shown that autoimmune disorders were related to the development of osteonecrosis. This study investigated the genetic effects of Interleukin 23 receptor (IL23R) polymorphisms regarding the risk of ONFH. Ten SNPs were selected and genotyped in 443 ONFH patients and 273 control subjects in order to perform the genetic association analysis. It was found that polymorphisms of the IL23R gene (rs4655686, rs1569922 and rs7539625) were significantly associated with an increased risk of ONFH (P values; 0.0198-0.0447, OR; 1.30-1.49). Particularly, a stratified analysis based on etiology (alcohol, steroid or idiopathic) showed that the associations between these polymorphisms and ONFH were most significant in idiopathic ONFH patients (P values; 0.0001-0.0150, OR; 1.45-2.17). These results suggest that IL23R polymorphisms may play an important role in the development of ONFH.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Abu-Shakra M / 2003 / Osteonecrosis in patients with SLE / Clin Rev Allergy Immunol 25 : 13 ~ 24
Asano T / 2003 / Genetic analysis of steroid-induced osteonecrosis of the femoral head / J Orthop Sci 8 : 329 ~ 33
Atsumi T / 1992 / Role of impairment of blood supply of the femoral head in the pathogenesis of idiopathic osteonecrosis / Clin Orthop Relat Res 277 : 22 ~ 30
Boss JH / 2004 / Experimentally gained insight - based proposal apropos the treatment of osteonecrosis of the femoral head / Med Hypotheses 62 : 958 ~ 65
Capon F / 2007 / Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis / Hum Genet 122 : 201 ~ 6
Asano T / 2003 / Genetic analysis of steroid-induced osteonecrosis of the femoral head / J Orthop Sci 8 : 329 ~ 33
Atsumi T / 1992 / Role of impairment of blood supply of the femoral head in the pathogenesis of idiopathic osteonecrosis / Clin Orthop Relat Res 277 : 22 ~ 30
Boss JH / 2004 / Experimentally gained insight - based proposal apropos the treatment of osteonecrosis of the femoral head / Med Hypotheses 62 : 958 ~ 65
Capon F / 2007 / Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis / Hum Genet 122 : 201 ~ 6
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