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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 128 - 132 (5page)
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초록· 키워드
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Interleukin 10 (IL10) is a powerful TH2-cel cyto-kine that inhibits lymphocyte replication and secretion of inflammatory cytokines. The genetic associations of polymorphisms in IL10 with clini-cal manifestations of tuberculosis (TB) were exa-mined in a large number of patients with clinical TB infection (n = 459) and normal controls (n = 871). One comon promoter SNP (IL10 -592 A＞C) was found to be significantly asociated with decreased risk of TB manifestation. The fre-quency of the "C"-bearing genotype was higher in normal controls than in patients with clinical TB infection (P = 0.005, OR = 0.69). A sumary of the genetic effect of IL10 -1082 A＞G, the other nearby promoter SNP, in other ethnic groups is also presented.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
/ / Assessment of the interleukin 1 gene cluster andother candidate gene polymorphisms in host susceptibility totuberculosis : 83 ~ 9
/ / Genetic restriction of HIV-1 pathogenesis to AIDS by promoteralleles of IL10 : 14467 ~ 72
/ / Genetics of atopy therationale behind promoter-based candidate gene studies
/ / IL-10 andTNF-alpha polymorphisms in a sample of Sicilian patientsaffected by tuberculosis implication for ageing and life spanexpectancy colonna-roma (g) : 569 ~ 72
/ / Immunogenetics of susceptibility to leprosy : 437 ~ 54
/ / Genetic restriction of HIV-1 pathogenesis to AIDS by promoteralleles of IL10 : 14467 ~ 72
/ / Genetics of atopy therationale behind promoter-based candidate gene studies
/ / IL-10 andTNF-alpha polymorphisms in a sample of Sicilian patientsaffected by tuberculosis implication for ageing and life spanexpectancy colonna-roma (g) : 569 ~ 72
/ / Immunogenetics of susceptibility to leprosy : 437 ~ 54
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