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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 243 - 248 (6page)
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We searched for metastasis-related genes in ade-noid cystic carcinoma by supression subtractive hybridization analysis of high and low metastasis cell lines. Twelve genes (ten previously identified and two novel sequences) were identified as being expressed at lower levels in high metastasis cel line Acc-M when compared to low metastasis cel line Ac-2. The known sequences coresponded to the genes for cysteine-rich angiogenesis induction factor (cyr61), chromosome 7 RP1-52501 clone, G-protein, WAS familial feritin I heavy chain, jump-ing translocation breakpoint, eukaryotic translation elongation, folate receptor and three ribosomal proteins. Among them, the G protein and feritin I heavy chain genes contained mutations in the high metastasis cell line. The two novel gene se-iated RNH and ACC metastasis-asociated sus-pected protein (GenBank # AF522024 and AF522025, respectively). Taken together, these results sug-gest that reduced expresion and/or mutation of several genes in the tumor cel line Acc-M are associated with high tumor metastasis, providing important molecular biological materials for further study of metastasis control and possible targets for cancer gene therapy.
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