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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 173 - 180 (8page)
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Recent trends in generating multiple, large-scale datasets provide new challenges to manipulating the relationship of different types of components, such as gene expression and drug response data. Integrative analysis of compound response and gene expression datasets generates an opportunity to capture the possible mechanism of compounds by using signature genes on diverse types of cancer cell lines. Here, we integrated datasets of compound response and gene expression profiles on NCI60 cell lines and constructed a network, revealing the relationship for 801 compounds and 341 gene probes. As examples, obtusol, which shows an exclusive sensitivity on a small number of colon cell lines, is related to a set of gene probes that have unique overexpression in colon cell lines. We also found that the SLC7A11 gene, a direct target of miR-26b, might be a key element in understanding the action of many diverse classes of anticancer compounds. We demonstrated that this network might be useful for studying the mechanisms of varied compound response on diverse cancer cell lines.
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참고문헌 (33)
참고문헌 신청
Ballif, B.C / 2011 / High-resolution array CGH defines critical regions and candidate genes for microcephaly, abnormalities of the corpus callosum, and seizure phenotypes in patients with microdeletions of 1q43q44 / Hum. Genet
Blower, P.E. / 2007 / MicroRNA expression profiles for the NCI-60 cancer cell panel / Mol. Cancer Ther 6:1483~1491
Chu, C.W / 2009 / Effect of data standardization on chemical clustering and similarity searching / J. Chem. Inf. Model 49:155~161
Cote, P.N / 1973 / Glucopyranosides derived from 2-hydroxy-1,4-naphthoquinones / Carbohydr. Res 26:247~251
Dai, Z / 2007 / Chemoinformatics analysis identifies cytotoxic compounds susceptible to chemoresistance mediated by glutathione and cystine/glutamate transport system xc / J. Med. Chem 50:1896~1906
Blower, P.E. / 2007 / MicroRNA expression profiles for the NCI-60 cancer cell panel / Mol. Cancer Ther 6:1483~1491
Chu, C.W / 2009 / Effect of data standardization on chemical clustering and similarity searching / J. Chem. Inf. Model 49:155~161
Cote, P.N / 1973 / Glucopyranosides derived from 2-hydroxy-1,4-naphthoquinones / Carbohydr. Res 26:247~251
Dai, Z / 2007 / Chemoinformatics analysis identifies cytotoxic compounds susceptible to chemoresistance mediated by glutathione and cystine/glutamate transport system xc / J. Med. Chem 50:1896~1906
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