지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 762 - 770 (9page)
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Osteoprotegerin (OPG) plays a core role in bone reformation by antagonizing the effect of receptor activator of nuclear factor κ-B ligand (RANKL), and mediates vascular calcification in cardiovascular disease patients. Thus, we aimed to examine the relationship between serum OPG levels and cardiovascular factors and inflammatory markers in metabolic syndrome patients (MS). This cross-sectional study included 96 men who visited the diet clinic between May and July 2011. Patients were classified into 2 groups based on NCEP-ATP guidelines: normal and with MS (n = 50 and 46, respectively). Physical measurements, biochemical assay were measured. Serum OPG and IL-6, diponectin and hs-CRP were assessed. MS were aged 50.02 ± 10.85 years, and normal patients 52.07 ± 9.56 years, with no significant differences. Significant differences were not observed in BMI between the 2 groups. Moreover, significant differences were not observed in serum OPG, however, the serum OPG level (4.41 ± 1.86 pmol/L) differed significantly between an overweight MS (BMI > 25) and normal patients. OPG was correlated to age (r = 0.410, p = 0.000), HDL-cholesterol (r = 0.209, p = 0.015), and log adiponectin (r = 0.175, p = 0.042). Multiple regression analyses using the enter method showed that age (β = 0.412, p = 0.000) and BMI (β = 0.265, p = 0.000) considerably affected OPG. In conclusion, out study showed that serum OPG levels are correlated with cardiovascular risk factors, such as BMI, HDL-cholesterol and adiponectin in MS and adiponectin, suggesting that serum OPG has potential as a cardiovascular disease indicator and predictor. (Korean J Community Nutr 16(6) : 762~770, 2011)
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참고문헌 (34)
참고문헌 신청
1. [학술지(정기간행물)] - Altinova AE / 2011 / Relationship between serum osteoprotegerin, glycemic control, renal function and markers of atherosclerosis in type 2 diabetes / Scand J Clin Lab Invest 71 (4) : 340 ~ 343
2. [학술지(정기간행물)] - Anand DV / 2006 / The relationship between plasma osteoprotegerin levels and coronary artery calcification in uncomplicated type 2 diabetic subjects / J Am Coll Cardiol 47 (9) : 1850 ~ 1857
3. [학술지(정기간행물)] - Arita Y / 1999 / Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity / Biochem Biophys Res Commun 257 : 79 ~ 83
4. [학술지(정기간행물)] - Ashley DT / 2011 / Similar to adiponectin, serum levels of osteoprotegerin are associated with obesity in healthy subjects / Metabolism 60 (7) : 994 ~ 1000
5. [학술지(정기간행물)] - Avignon A / 2005 / Osteoprotegerin is associated with silent coronary artery disease in high-risk but asymptomatic type 2 diabetic patients / Diabetes Care 28 : 2176 ~ 2180
2. [학술지(정기간행물)] - Anand DV / 2006 / The relationship between plasma osteoprotegerin levels and coronary artery calcification in uncomplicated type 2 diabetic subjects / J Am Coll Cardiol 47 (9) : 1850 ~ 1857
3. [학술지(정기간행물)] - Arita Y / 1999 / Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity / Biochem Biophys Res Commun 257 : 79 ~ 83
4. [학술지(정기간행물)] - Ashley DT / 2011 / Similar to adiponectin, serum levels of osteoprotegerin are associated with obesity in healthy subjects / Metabolism 60 (7) : 994 ~ 1000
5. [학술지(정기간행물)] - Avignon A / 2005 / Osteoprotegerin is associated with silent coronary artery disease in high-risk but asymptomatic type 2 diabetic patients / Diabetes Care 28 : 2176 ~ 2180
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