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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
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- 1 - 12 (12page)
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Neuro-osteological interactions have an important role in the regulation of bone metabolism and regeneration. Neuropeptides combined with porous biphasic calcium phosphates (BCP) using protein adsorption may contribute to the acceleration of bone formation. In the present study, we investigated the effect of BCP combined with nerve growth factor (NGF) on the growth of osteoblasts in vitro and the combinational therapeutic effect on the repair of calvarial defects in vivo. NGF was separated and purified from Chinese cobra venom using a simplified three-step chromatography method. BCP combined with NGF exerted a potent effect on osteoblast differentiation, as evidenced by enhanced cell proliferation, increased ALP activity and the upregulated expression of osteogenesis-related genes and proteins. Further, combinational therapy with BCP and NGF improved calvarial regeneration, which was superior to treatment with therapy alone, as observed using imageological and morphological examination and histological and immunohistochemical staining. The results confirmed the effect of neuro-osteological interactions through combinatorial treatment with NGF and BCP to promote osteogenesis and bone formation, which may provide an effective and economical strategy for clinical application.
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참고문헌 (20)
참고문헌 신청
Arumae U / 1989 / Sensitive time-resolved fluoroimmunoassay of nerve growth factor and the disappearance of nerve growth factor from rat pheochromocytoma PC12 cell culture m
Bodde EW / 2007 / Bone regeneration of porous beta-tricalcium phosphate(Conduit TCP)and of biphasic calcium phosphate ceramic(Biosel)in trabecular defects in sheep / J Biomed
Cao J / 2012 / Local injection of nerve growth factor via a hydrogel enhances bone formation during mandibular distraction osteogenesis / Oral Surg Oral Med Oral Pathol oral
Chung SM / 2016 / Evaluation of different combinations of biphasic calcium phosphate and growth factors for bone formation in calvarial defects in a rabbit model / Int J Peri
Farina NM / 2008 / In vivo behaviour of two different biphasic ceramic implanted in mandibular bone of dogs / J Mater Sci Mater Med 19 : 1565 ~ 1573
Bodde EW / 2007 / Bone regeneration of porous beta-tricalcium phosphate(Conduit TCP)and of biphasic calcium phosphate ceramic(Biosel)in trabecular defects in sheep / J Biomed
Cao J / 2012 / Local injection of nerve growth factor via a hydrogel enhances bone formation during mandibular distraction osteogenesis / Oral Surg Oral Med Oral Pathol oral
Chung SM / 2016 / Evaluation of different combinations of biphasic calcium phosphate and growth factors for bone formation in calvarial defects in a rabbit model / Int J Peri
Farina NM / 2008 / In vivo behaviour of two different biphasic ceramic implanted in mandibular bone of dogs / J Mater Sci Mater Med 19 : 1565 ~ 1573
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