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논문 기본 정보

자료유형
학술저널
저자정보
Yang Gang (Stomatologic Hospital and College Anhui Medical University) Liu Xin (Oral and Maxillofacial Center Stomatologic Hospital) Huang Tianyu (Stomatologic Hospital and College Anhui Medical University) Ding Ruyuan (Stomatologic Hospital and College Anhui Medical University) Wang Yuanyin (Stomatologic Hospital and College Anhui Medical University)
저널정보
한국조직공학과 재생의학회 조직공학과 재생의학 조직공학과 재생의학 제20권 제1호
발행연도
2023.2
수록면
93 - 109 (17page)
DOI
10.1007/s13770-022-00502-z

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Background: Teeth can be used as a raw material for preparing bone substitutes due to their similar chemical composition to bone. The objective of our study was to evaluate the effect of odontogenic biphasic calcium phosphate (BCP) incorporating dentin noncollagenous proteins (DNCPs) on osteogenesis and stability in maxillary sinus augmentation. Methods: The composition, structure and morphology of the odontogenic BCP were tested by X-ray powder diffraction (XRD), Brunauer–Emmett–Teller, and scanning electron microscopy methods. The biocompatibility and osteoinduction of DNCPs and materials were examined in vitro and their bone regeneration capacity was verified in vivo. Results: The results showed that the cells adhered and proliferated well on the DNCP-loaded BCP scaffold. The odontogenic BCP and DNCPs promoted osteogenic differentiation of cells, The new bone formation in the BCP groups and DNCP subgroups was significantly higher than the new bone formation in the control, and the new bone quality was better. The bone regeneration effect of odontogenic BCP was similar to the effect of deproteinized bovine bone mineral, but β-TCP did not maintain the height and volume of bone reconstruction. Conclusion: In conclusion, the combined application of DNCPs and odontogenic BCP is an effective strategy for tissue engineering osteogenesis in the maxillary sinus region. The biomimetic strategy could provide a new approach for patients requiring maxillary sinus lifting.

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