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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 317 - 326 (10page)
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초록· 키워드
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Recurrent laryngeal nerve (RLN) injury can result in unilateral or bilateral vocal cords paralysis, thereby causing a series of complications, such as hoarseness and dyspnea. However, the repair of RLN remains a great challenge in current medicine. This study aimed to develop human umbilical mesenchymal stem cells (HuMSCs) and nerve growth factor (NGF)-loaded heparinized collagen scaffolds (HuMSCs/NGF HC-scaffolds) and evaluate their potential in the repair of RLN injury. HuMSCs/NGF HC-scaffolds were prepared through incorporating HuMSCs and NGF into heparinized collagen scaffolds that were prefabricated by freeze-drying in a template. The resulting scaffolds were characterized by FTIR, SEM, porosity, degradation in vitro, NGF release in vitro and bioactivity. A rabbit RLN injury model was constructed to appraise the performance of HuMSCs/NGF HC-scaffolds for nerve injury repair. Electrophysiology, histomorphology and diagnostic proteins expression for treated nerves were checked after application of various scaffolds. The results showed that the composite scaffolds with HuMSCs and NGF were rather helpful for the repair of broken RLN. The RLN treated with HuMSCs/NGF HC-scaffolds for 8 weeks produced a relatively normal electromyogram, and the levels of calciumbinding protein S100, neurofilament and AchE pertinent to nerve were found to be close to the normal ones but higher than those resulted from other scaffolds. Taken together, HuMSCs/NGF HC-scaffolds exhibited a high score on the nerve injury repair and may be valuable for the remedy of RLN injury.
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등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Siebert JR / 2015 / Biomaterial approaches to enhancing neurorestoration after spinal cord injury : strategies for overcoming inherent biological obstacles / Biomed Res Int 2015:752572
Ma J / 2011 / Micturition reflex arc reconstruction including sensory and motor nerves after spinal cord injury : urodynamic and electrophysiological responses / J Spinal Cord Med 34:510~517
Zhang SC / 2006 / Intradural lysis and peripheral nerve implantation for traumatic obsolete incomplete paralysis / Surg Technol Int 15:276~281
He Y / 2016 / Development of synthetic and natural materials for tissue engineering applications using adipose stem cells / Stem Cells Int 2016:5786257
Hsu SH / 2013 / New nerve regeneration strategy combining laminin-coated chitosan conduits and stem cell therapy / Acta Biomater 9:6606~6615
Ma J / 2011 / Micturition reflex arc reconstruction including sensory and motor nerves after spinal cord injury : urodynamic and electrophysiological responses / J Spinal Cord Med 34:510~517
Zhang SC / 2006 / Intradural lysis and peripheral nerve implantation for traumatic obsolete incomplete paralysis / Surg Technol Int 15:276~281
He Y / 2016 / Development of synthetic and natural materials for tissue engineering applications using adipose stem cells / Stem Cells Int 2016:5786257
Hsu SH / 2013 / New nerve regeneration strategy combining laminin-coated chitosan conduits and stem cell therapy / Acta Biomater 9:6606~6615
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