지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1 - 14 (14page)
이용수
초록· 키워드
오류제보하기
This study investigated the regulatory role of nerve growth factor (NGF) in sirtuin 1 (SIRT1) expression in cholestatic livers. We evaluated the expression of NGF and its cognate receptors in human livers with hepatolithiasis and the effects of NGF therapy on liver injury and hepatic SIRT1 expression in a bile duct ligation (BDL) mouse model. Histopathological and molecular analyses showed that the hepatocytes of human diseased livers expressed NGF, proNGF (a precursor of NGF), TrkA and p75NTR, whereas only p75NTR was upregulated in hepatolithiasis, compared with non-hepatolithiasis livers. In the BDL model without NGF therapy, p75NTR, but not TrkA antagonism, significantly deteriorated BDL-induced liver injury. By contrast, the hepatoprotective effect of NGF was abrogated only by TrkA and not by p75NTR antagonism in animals receiving NGF therapy. Intriguingly, a positive correlation between hepatic SIRT1 and NGF expression was found in human livers. In vitro studies demonstrated that NGF upregulated SIRT1 expression in mouse livers and human Huh-7 and rodent hepatocytes. Both NGF and proNGF induced protective effects against hydrogen peroxide-induced cytotoxicity in Huh-7 cells, whereas inhibition of TrkA and p75NTR activity prevented oxidative cell death. Mechanistically, NGF, but not proNGF, upregulated SIRT1 expression in human Huh-7 and rodent hepatocytes via nuclear factor (NF)-κB activity, whereas NGF-induced phosphoinositide-3 kinase/Akt, extracellular signal–regulated kinase and NF-κB signaling and SIRT1 activity were involved in its hepatoprotective effects against oxidative injury. These findings suggest that pharmacological manipulation of the NGF/SIRT1 axis might serve as a novel approach for the treatment of cholestatic disease.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Proteomic analysis of novel targets associated with the enhancement of TrkA-induced SK-N-MC cancer cell death caused by NGF
Experimental and Molecular Medicine
2016 .01
-
Synthesis of Nerve Growth Factor Vector for the Treatment of Glaucoma by Regeneration of Retinal Ganglion Cell Layer
한국생물공학회 학술대회
2015 .10
-
Guangxi cobra venom-derived NGF promotes the osteogenic and therapeutic effects of porous BCP ceramic
Experimental and Molecular Medicine
2017 .01
-
Insights into the Therapeutic Potential of Heparinized Collagen Scaffolds Loading Human Umbilical Cord Mesenchymal Stem Cells and Nerve Growth Factor for the Repair of Recurrent Laryngeal Nerve Injury
조직공학과 재생의학
2017 .01
-
MDM2-dependent Sirt1 degradation is a prerequisite for Sirt6-mediated cell death in head and neck cancers
Experimental and Molecular Medicine
2021 .03
-
Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possible involvement of ER stress and S6K1 activation
BMB Reports
2019 .01
-
Correction: Guangxi cobra venom-derived NGF promotes the osteogenic and therapeutic effects of porous BCP ceramic
Experimental and Molecular Medicine
2020 .01
-
Author Correction: Guangxi cobra venom-derived NGF promotes the osteogenic and therapeutic effects of porous BCP ceramic
Experimental and Molecular Medicine
2019 .01
-
SIRT1 inhibits monocyte adhesion to the vascular endothelium by suppressing Mac-1 expression on monocytes
Experimental and Molecular Medicine
2019 .01
-
Extremely Low-frequency Electromagnetic Fields Enhance Neuronal Differentiation of NGF Induced PC12 Cells
한국생물공학회 학술대회
2015 .04
-
SIRT1 ubiquitination is regulated by opposing activities of APC/C-Cdh1 and AROS during stress-induced premature senescence
Experimental and Molecular Medicine
2023 .06
-
Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1
Experimental and Molecular Medicine
2021 .09
-
Current Understanding of Stem Cell and Secretome Therapies in Liver Diseases
조직공학과 재생의학
2017 .01
-
Loss of hepatic Sirt7 accelerates diethylnitrosamine (DEN)-induced formation of hepatocellular carcinoma by impairing DNA damage repair
BMB Reports
2024 .02
-
Adipose sirtuin 6 drives macrophage polarization toward M2 through IL-4 production and maintains systemic insulin sensitivity in mice and humans
Experimental and Molecular Medicine
2019 .01
-
Neuroprotective and Neurorestorative Role of Lactucopicrin in Neuronal via Ca 2+ / CaMKII / ATF1 Neuritogenesis and trophic Factor Mediated potentiation in Non-Neuronal cells
한국생물공학회 학술대회
2015 .04
-
Loss of Sirt6 in adipocytes impairs the ability of adipose tissue to adapt to intermittent fasting
Experimental and Molecular Medicine
2021 .09
-
Liver Organoids: Formation Strategies and Biomedical Applications
조직공학과 재생의학
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0