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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 491 - 498 (8page)
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Axin is a negative regulator of the Wnt/β-catenin path-way and is involved in the regulation of axis formation and proliferation. Involvement of Axin in the regulation of other signaling pathways is poorly understood. In growth regulation by Axin in L929 fibroblasts stimu-lated by EGF. Akt activity was increased by EGF treat-ment and Ras activation, respectively. Both the EGF- and Ras-induced Akt activations were abolished by Axin induction, as revealed by both Western blot and imunocytochemical analyses. The proliferation and Akt activation induced by EGF were decreased by Axin induction, and the efects of EGF were abolished by treatment of an Akt-specific inhibitor. Therefore, Axin by blocking Akt activation.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Behrens J / 1998 / Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta 280 : 596 ~ 599
Cannon ML / 2004 / The KSHV G protein-coupled receptor signals via multiple pathways to induce transcription factor activation in primary effusion lymphoma cells 23 : 514 ~ 5
Clevers H / 2000 / Axin and hepatocellular carcinomas 24 : 206 ~ 208
Dihlmann S / 2005 / Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells 26 : 1503 ~ 1512
Gao N / 2004 / G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells 287 : 281 ~ 291
Cannon ML / 2004 / The KSHV G protein-coupled receptor signals via multiple pathways to induce transcription factor activation in primary effusion lymphoma cells 23 : 514 ~ 5
Clevers H / 2000 / Axin and hepatocellular carcinomas 24 : 206 ~ 208
Dihlmann S / 2005 / Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells 26 : 1503 ~ 1512
Gao N / 2004 / G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells 287 : 281 ~ 291
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