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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제16권 제3호
- 발행연도
- 2006.1
- 수록면
- 391 - 398 (8page)
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NF-κB is a transcription factor involved in theIt is also known to render cells resistant to the apoptosis causedby some anticancer drugs. Such a chemoresistance of cancercels may be related to the activation of NF-κB transcriptionfactor; however, the mechanism of activation is not wellunderstood. Here, we demonstrate that a chemotherapeuticagent, etoposide, independently stimulates the IκBα degradationpathway and PI3-kinase/Akt signaling pathway: The classicalIκBα degradation pathway leads to the nuclear translocationβ kinase,whereas the PI3-kinase/Akt pathway plays a distinct role inactivating this transcription factor. The PI3-kinase/Akt pathwayacts on the p50 subunit of the NF-κB transcription factor andenhances the DNA binding afinity of the p50 protein. It mayalso explain the role of the PI3-kinase/Akt pathway in theanti-apoptotic function of NF-κB during chemoresistance ofcancer cells.
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참고문헌 (23)
참고문헌 신청
Anrather, J / 2005 / Cis-acting element-specific transcriptional activity of differentially phosphorylated NF-κB / J. Biol. Chem. 280 : 244 ~ 252
Arlt, A / 2001 / Inhibition of NF-κB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin / Oncogene 20 : 859 ~ 868
Arlt, A / 2003 / Role of NF-κB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death / Oncogene 22 : 3243 ~ 3251
Beg, A. A / 1995 / Constitutive NF-κB activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alphadeficient mice / Genes Dev. 9 : 2736 ~ 2746
Bottero, V / 2001 / Activation of NF-κB through the IKK complex by the topoisomerase poisons SN38 and doxorubicin: A brake to apoptosis in HeLa human carcinoma cells / Cance
Arlt, A / 2001 / Inhibition of NF-κB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin / Oncogene 20 : 859 ~ 868
Arlt, A / 2003 / Role of NF-κB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death / Oncogene 22 : 3243 ~ 3251
Beg, A. A / 1995 / Constitutive NF-κB activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alphadeficient mice / Genes Dev. 9 : 2736 ~ 2746
Bottero, V / 2001 / Activation of NF-κB through the IKK complex by the topoisomerase poisons SN38 and doxorubicin: A brake to apoptosis in HeLa human carcinoma cells / Cance
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