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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제4호
- 발행연도
- 2008.1
- 수록면
- 682 - 685 (4page)
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초록· 키워드
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Among thirteen strains of the genus Bacillus isolated from Shrimp-jeotkal in our laboratory, a strain BA34 showing good antifungal activity against Phytophthora infestans in a previous experiment was tested for the inhibitory effect against Akt, protein kinase B. Since Akt is known to play an important role in controlling apoptosis, its inhibitors can be used as potential apoptosis-inducing agents in the treatment of cancer. Two active compounds were isolated and their structures were determined. They have similar structures, despite showing different inhibitory effects. In order to elucidate the reasons for these different effects, three-dimensional studies were carried out.
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참고문헌 (12)
참고문헌 신청
Datta, S. R. / 1999 / Cellular survival: A play in three Akts / Genes Dev 13 : 2905 ~ 2927
Downward, J. / 1998 / Mechanisms and consequences of activation of protein kinase B/Akt. Curr. Opin / Cell Biol 10 : 262 ~ 267
KIM, HYESOOK / 2006 / Antifungal Activity of Bacillus sp. Against Phytophthora infestans / Journal of Microbiology and Biotechnology 16 (3) : 487 ~ 490
Kim, C. G. / 2007 / Tamoxifen-induced activation of p21Waf1/Cip1 gene transcription is mediated by Early Growth Response-1 protein through the JNK and p38 MAP kinase/Elk-1 ca
LEE, CHUL-HOON / 2006 / An Antifungal Property of Burkholderia ambifaria Against Phytopathogenic Fung / Journal of Microbiology and Biotechnology 16 (3) : 465 ~ 468
Downward, J. / 1998 / Mechanisms and consequences of activation of protein kinase B/Akt. Curr. Opin / Cell Biol 10 : 262 ~ 267
KIM, HYESOOK / 2006 / Antifungal Activity of Bacillus sp. Against Phytophthora infestans / Journal of Microbiology and Biotechnology 16 (3) : 487 ~ 490
Kim, C. G. / 2007 / Tamoxifen-induced activation of p21Waf1/Cip1 gene transcription is mediated by Early Growth Response-1 protein through the JNK and p38 MAP kinase/Elk-1 ca
LEE, CHUL-HOON / 2006 / An Antifungal Property of Burkholderia ambifaria Against Phytopathogenic Fung / Journal of Microbiology and Biotechnology 16 (3) : 465 ~ 468
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