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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 574 - 582 (9page)
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Xenotransplantation, the transplantation of cells, tissues or organs between individuals of different species, would resolve the current shortage of organs, but rejection remains the major hurdle to successful xenotransplantation. In the present study, we analyzed mixed lymphocyte reactions (MLRs) and used 51Cr release assays in order to identify the proliferation and expansion of mouse CD8+cytotoxic T lymphocyte cells against PK15, PK15/pIL-18 or PK15/mIL-18 cells. In addition, we identified T cell populations in mouse splenocytes and lymph node cells using two-color flow cytometry. It was found that the CD8+ T cells of xenograft recipients proliferated extensively and that the survival rates of populations of PK15/mIL-18 or PK15/pIL-18 cells were higher than untransfected controls. Moreover, CD3+T cells were increased in mice injected with PK15 cells or PK15/pIL-18 cells but PK15/pIL-18 cell numbers were lower in lymph nodes than untransfected controls. CD8+ T cells numbers were reduced in the lymph nodes of PK15/pIL-18 injected mice. These results suggest that porcine IL-18 regulates anti-pig cellular rejection in C57BL/6 mice.
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참고문헌 (15)
참고문헌 신청
/ / Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction : 156 ~ 9
/ 1997 / Accommodation of vascularized xenografts expression of protective genes by donor endothelial cells in a host Th2 cytokine environment 3 : 196 ~ 203
/ 1997 / Interleukin 18 enhances Fas ligand expression and induces apoptosis Fas expressing human myelomono cytic KG1 cells 17 : 3253 ~ 3258
/ 2000 / Cloning Sequencing and expression of porcine interleukin18 in Escherichia coli 10 : 343 ~ 347
/ 2000 / Naturally developing memory T cell xenoreactivity to swine antigens in human peripheral blood lymphocytes 164 : 2790 ~ 2796
/ 1997 / Accommodation of vascularized xenografts expression of protective genes by donor endothelial cells in a host Th2 cytokine environment 3 : 196 ~ 203
/ 1997 / Interleukin 18 enhances Fas ligand expression and induces apoptosis Fas expressing human myelomono cytic KG1 cells 17 : 3253 ~ 3258
/ 2000 / Cloning Sequencing and expression of porcine interleukin18 in Escherichia coli 10 : 343 ~ 347
/ 2000 / Naturally developing memory T cell xenoreactivity to swine antigens in human peripheral blood lymphocytes 164 : 2790 ~ 2796
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