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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 144 - 152 (9page)
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We have previously isolated a novel protein B/K that contains two C2-like domains. Here, we report the isolatioin and mRNA distribution of a human B/K isoform, and protein kinase A (PKA)-dependent phosphorylation of the B/K protein. The 1.5 kb human B/K cDNA clone exhibits 89% and 97% identities with respectively. Human B/K isoform encodes a 474 amino acid protein and shows structural features similar to the rat counterpart including two C2 domains, three consensus sequences for PKA, absence of a transmembrane region, and con-servation of the N-terminal cysteine cluster. On Northern and dot blot analyses, a 3.0 kb B/K transcript was abundantly present in human brain, kidney, and prostate. Among the brain regions, strong signals were observed in the frontal and temporal lobes, the hippocampus, the hypothalamus, the amygdala, the substantia nigra, and the pituitary. Recombinant B/K proteins containing three consensus sites for PKA was very efficiently phosphorylated in vitro by PKA catalytic subunit. B/K protein which was over-expressed in LLC-PK1 cells was also strongly phosphorylated in vivo by vasopressin analog DDAVP, and PKA-specific inhibitor H89 as well as type 2 vasopressin receptor antagonist specifically suppressed DDAVP-induced B/K phosphorylation. These results suggest that B/K proteins play a role as potential substrates for PKA in the area where they are expressed.
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참고문헌 (30)
참고문헌 신청
[학술지(정기
/ / 5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II nii i (be m sitol-1) : 29206 ~ 11
/ 1989 / The protein kinase C fam-ily:heterogeneity and its implications 58 : 31 ~ 44
/ 1993 / Interaction of synaptotagmin with the cytoplasmic domains of neurexins 10 : 307 ~ 15
/ 1994 / Phosphor-ylation of Rabphilin-3A a putative target protein for Rab3A
/ / 5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II nii i (be m sitol-1) : 29206 ~ 11
/ 1989 / The protein kinase C fam-ily:heterogeneity and its implications 58 : 31 ~ 44
/ 1993 / Interaction of synaptotagmin with the cytoplasmic domains of neurexins 10 : 307 ~ 15
/ 1994 / Phosphor-ylation of Rabphilin-3A a putative target protein for Rab3A
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